DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5382 and ZFPL1

DIOPT Version :9

Sequence 1:	NP_732721.1	Gene:	CG5382 / 42618	FlyBaseID:	FBgn0038950	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_006773.2	Gene:	ZFPL1 / 7542	HGNCID:	12868	Length:	310	Species:	Homo sapiens

Alignment Length:	316	Identity:	132/316 - (41%)
Similarity:	170/316 - (53%)	Gaps:	38/316 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLCKCPKRLVTNQFCFEHRVNVCEHCMVQSHPKCIVQSYLQWLRDSDYISNCTLCGTTLEQGDC 65
            |||||||||.|||.|||||||||||||:|.:|.|||||||||||:||||..||.||...|...:.
Human     1 MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHAKCIVQSYLQWLQDSDYNPNCRLCNIPLASRET 65

  Fly    66 VRLVCYHVFHWDCLNARQAALPANTAPRGHQCPACSVEIFPNANLVSPVADALKSFLSQVNWGRN 130
            .|||||.:|||.|||.|.|.||.||||.|:|||:|:..|||..||..|||.||:..|:.|||.|.
Human    66 TRLVCYDLFHWACLNERAAQLPRNTAPAGYQCPSCNGPIFPPTNLAGPVASALREKLATVNWARA 130

  Fly   131 GLGLALLSEEQSSSLKAIKPKVASQAAVSNMTKVHHIHSGGERERTKPNGHDAVSPHSVLLMDAF 195
            ||||.|:.|..|.     :|:..:.:..|:.:..:...:.|      |...|:.|........|.
Human   131 GLGLPLIDEVVSP-----EPEPLNTSDFSDWSSFNASSTPG------PEEVDSASAAPAFYSQAP 184

  Fly   196 NPPSAGD--------YASSRRPL--LPR---------QSPIGGTDRDDNKYQRRTPAELFSRWTR 241
            .||::..        :..:..||  .||         ::|....|.||:||:||......:|..|
Human   185 RPPASPGRPEQHTVIHMGNPEPLTHAPRKVYDTRDDDRTPGLHGDCDDDKYRRRPALGWLARLLR 249

  Fly   242 RFYAPSSRP--PWRRTWFLVTAGILAFVLFVYLMAWLGRGGSDAVDEGWNNPNPQP 295
            .......||  ..:|...|:..|:|.|:..:.||:.|||..:|      ::||..|
Human   250 SRAGSRKRPLTLLQRAGLLLLLGLLGFLALLALMSRLGRAAAD------SDPNLDP 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5382	NP_732721.1	zf-RING_2	52..100	CDD:290367	28/47 (60%)
CG5382	NP_732721.1	TctB	<235..>277	CDD:284693	11/43 (26%)
ZFPL1	NP_006773.2	mRING-H2-C3DHC3_ZFPL1	50..104	CDD:319401	29/53 (55%)
		modified RING-H2 finger (C3DHC3-type)	53..100	CDD:319401	27/46 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..231		15/91 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147115
Domainoid	1	1.000	221	1.000	Domainoid score	I2613
eggNOG	1	0.900	-	-		E1_KOG3970
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4935
Inparanoid	1	1.050	222	1.000	Inparanoid score	I3547
Isobase	1	0.950	-	0	Normalized mean entropy	S3613
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489858at33208
OrthoFinder	1	1.000	-	-		FOG0006162
OrthoInspector	1	1.000	-	-		oto90462
orthoMCL	1	0.900	-	-		OOG6_105755
Panther	1	1.100	-	-	LDO	PTHR12981
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4450
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.710