Protein Alignment rdhB and CBR4

DIOPT Version :10

• Sequence 1: NP_651024.1
• Gene: rdhB / 42614
• FlyBaseID: FBgn0038946
• Length: 248
• Species: Drosophila melanogaster
• Sequence 2: XP_006714454.1
• Gene: CBR4 / 84869
• HGNCID: 25891
• Length: 247
• Species: Homo sapiens
• Alignment Length: 247
• Identity: 58/247 - (23%)
• Similarity: 107/247 - (43%)
• Gaps: 42/247 - (17%)

  Fly     9 NKVAVVTGASVGIGATTAIELANAGMVVVGLARRVELIEALRDQVTGVGKIFARQCDLNDEEQLA 73
            :||..|.|.|.|||...|..:|..|..:..:||.:|..:|....:.|....|:  ||:..|..:.
Human     2 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS--CDVAKEHDVQ 64

  Fly    74 SAFNWIREKFQAIHVLICNAGILKANFLSESPTKDIKELFDTNVVATASCLREALKHMAAVKVRG 138
            :.|..:.:....::.|:..|||.:...|..:.|:|:.....||::.:....:.|::.|  ::.:|
Human    65 NTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTM--IQQQG 127

  Fly   139 HIVVMNSVLGHRIPEV-----PVPL-----FSVYPATKHAITALCQTVRQEIHFLKLNIKLTSIC 193
            ..:|.   :|||...:     .|.|     .|||.|:|..:....:.:.:|:  .:..|::..:.
Human   128 GSIVN---VGHRREMLLHKRSIVGLKGNSGQSVYSASKGGLVGFSRALAKEV--ARKKIRVNVVA 187

  Fly   194 PGMVDTDF--------------LSVYSQAVAELPKLQARDVAKAVLYALNTP 231
            ||.|.||.              |..:.:.:         :||.||::.|.:|
Human   188 PGFVHTDMTKDLKEEHLKKNIPLGRFGETI---------EVAHAVVFLLESP 230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdhB	NP_651024.1	Mgc4172-like_SDR_c	4..244	CDD:187601	58/247 (23%)
CBR4	XP_006714454.1	Rossmann-fold NAD(P)(+)-binding proteins	3..243	CDD:473865	58/246 (24%)