Protein Alignment rdhB and RDH8

DIOPT Version :10

• Sequence 1: NP_651024.1
• Gene: rdhB / 42614
• FlyBaseID: FBgn0038946
• Length: 248
• Species: Drosophila melanogaster
• Sequence 2: NP_056540.3
• Gene: RDH8 / 50700
• HGNCID: 14423
• Length: 311
• Species: Homo sapiens
• Alignment Length: 221
• Identity: 56/221 - (25%)
• Similarity: 103/221 - (46%)
• Gaps: 37/221 - (16%)

  Fly    10 KVAVVTGASVGIGATTAIELANAGMVVVGLARRVELIEALRDQVTGVGK---------------I 59
            :..:::|.|.|||...|::||:      ...:|.:::..:||    :||               :
Human     6 RTVLISGCSSGIGLELAVQLAH------DPKKRYQVVATMRD----LGKKETLEAAAGEALGQTL 60

  Fly    60 FARQCDLNDEEQLASAFNWIREKFQAIHVLICNAGILKANFLSESPTKDIKELFDTNVVATASCL 124
            ...|.|:..:|.:|...:.|:.:   :.||:.|||:.....|.......::.:||||.......:
Human    61 TVAQLDVCSDESVAQCLSCIQGE---VDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLV 122

  Fly   125 REALKHMAAVKVRGHIVVMNSVLGHRIPEVPVPLFSVYPATKHAITALCQTVRQEIHFLKLNIKL 189
            :..|..|.. :.:|||||::||:|.:    .|....||.|:|.|:....:::  .|..|:.||.:
Human   123 KAVLPGMKR-RRQGHIVVISSVMGLQ----GVIFNDVYAASKFALEGFFESL--AIQLLQFNIFI 180

  Fly   190 TSICPGMVDTDFLS--VYSQAVAELP 213
            :.:.||.|.|:|..  :...::||.|
Human   181 SLVEPGPVVTEFEGKLLAQVSMAEFP 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdhB	NP_651024.1	Mgc4172-like_SDR_c	4..244	CDD:187601	56/221 (25%)
RDH8	NP_056540.3	type1_17beta-HSD-like_SDR_c	6..262	CDD:187666	56/221 (25%)