DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdhB and HSD11B1L

DIOPT Version :9

Sequence 1:	NP_001262831.1	Gene:	rdhB / 42614	FlyBaseID:	FBgn0038946	Length:	248	Species:	Drosophila melanogaster
Sequence 2:	NP_001254797.1	Gene:	HSD11B1L / 374875	HGNCID:	30419	Length:	333	Species:	Homo sapiens

Alignment Length:	237	Identity:	59/237 - (24%)
Similarity:	99/237 - (41%)	Gaps:	30/237 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FYWRNKV---------AVVTGASVGIGATTAIELANAGMVVVGLARRVELIEALRDQVT------ 54
            :||.:..         .::|||:.|:|...|...|..|..:|..|.    .|||..:|.
Human    63 YYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAH----TEALLQKVVGNCRKL 123

  Fly    55 GVGKIFARQCDLNDEEQLASAFNWIREKFQAIHVLICN-AGILKANFLSESPTKDIKELFDTNVV 118
            |..|:|....|:...|...|...:..:|...:..|:.| .|...|...:.|| :..:.|...|.|
Human   124 GAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSP-QATRWLMQVNFV 187

  Fly   119 ATASCLREALKHMAAVKVRGHIVVMNSVLGHRIPEVPVPLFSVYPATKHAITALCQTVRQEIHFL 183
            :.......||..:...|  |.:||::|:||    .||....:.|.|.|.|:.....::|:|:...
Human   188 SYVQLTSRALPSLTDSK--GSLVVVSSLLG----RVPTSFSTPYSAAKFALDGFFGSLRRELDVQ 246

  Fly   184 KLNIKLTSICPGMVDTDFLSVYSQAVAELPKLQARDVAKAVL 225
            .:|:.:|....|:.|.   :..::||..:.:::|....||.|
Human   247 DVNVAITMCVLGLRDR---ASAAEAVRGVTRVKAAPGPKAAL 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdhB	NP_001262831.1	Mgc4172-like_SDR_c	4..244	CDD:187601	59/237 (25%)
rdhB	NP_001262831.1	YdfG	9..241	CDD:226674	57/233 (24%)
HSD11B1L	NP_001254797.1	GVQW	3..>26	CDD:290611
		NADB_Rossmann	74..302	CDD:304358	57/226 (25%)
		PRK08251	78..302	CDD:181324	57/222 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810