DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rdhB and HSD17B1

DIOPT Version :10

Sequence 1:NP_651024.1 Gene:rdhB / 42614 FlyBaseID:FBgn0038946 Length:248 Species:Drosophila melanogaster
Sequence 2:NP_001317148.1 Gene:HSD17B1 / 3292 HGNCID:5210 Length:329 Species:Homo sapiens


Alignment Length:255 Identity:66/255 - (25%)
Similarity:102/255 - (40%) Gaps:44/255 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 VAVVTGASVGIGATTAIELA---NAGMVVVGLARRVE----LIEALRDQVTGVGKIFARQCDLND 68
            |.::||.|.|||...|:.||   :....|....|.::    |.||.|......|.:...|.|:.|
Human     5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRD 69

  Fly    69 EEQLASAFNWIREKFQAIHVLICNAGILKANFLSESPTKDIKELFDTNVVATASCLREALKHMAA 133
            .:.:|:|...:.|  ..:.||:||||:.....|.......:..:.|.|||.|...|:..|..|..
Human    70 SKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKR 132

  Fly   134 VKVRGHIVVMNSVLGHRIPEVPVPLFSVYPATKHAITALCQTVRQEIHFLKLNIKLTSI--CPGM 196
             :..|.::|..||.|    .:.:|...||.|:|.|:..||:::  .:..|...:...|:  | |.
Human   133 -RGSGRVLVTGSVGG----LMGLPFNDVYCASKFALEGLCESL--AVLLLPFGVHSLSLIEC-GP 189

  Fly   197 VDTDFLS-------------------------VYSQAVAELPKLQARDVAKAVLYALNTP 231
            |.|.|:.                         .:|:.|.........:||:..|.||..|
Human   190 VHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAP 249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rdhBNP_651024.1 Mgc4172-like_SDR_c 4..244 CDD:187601 66/255 (26%)
HSD17B1NP_001317148.1 Rossmann-fold NAD(P)(+)-binding proteins 4..262 CDD:473865 66/255 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..329
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.