Protein Alignment rdhB and HSD11B1

DIOPT Version :9

• Sequence 1: NP_001262831.1
• Gene: rdhB / 42614
• FlyBaseID: FBgn0038946
• Length: 248
• Species: Drosophila melanogaster
• Sequence 2: NP_001193670.1
• Gene: HSD11B1 / 3290
• HGNCID: 5208
• Length: 292
• Species: Homo sapiens
• Alignment Length: 219
• Identity: 57/219 - (26%)
• Similarity: 97/219 - (44%)
• Gaps: 25/219 - (11%)

  Fly     8 RNKVAVVTGASVGIGATTAIELANAGMVVVGLARRVELIEALRDQVTGVGKIFARQC-----DLN 67
            :.|..:|||||.|||...|..||..|..||..||..|.::.:......:|...|...     |:.
Human    33 QGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMT 97

  Fly    68 DEEQLASAFNWIREKFQAIHVLICNAGILKANFLSESPTKDIKELFDTN----VVATASCLREAL 128
            ..||..:...   :....:.:||.|.....:..|.......:::..:.|    ||.|.:.| ..|
Human    98 FAEQFVAQAG---KLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAAL-PML 158

  Fly   129 KHMAAVKVRGHIVVMNSVLGHRIPEVPVPLFSVYPATKHAITALCQTVRQEIHFLKLNIKLTSIC 193
            |     :..|.|||::|:.|    :|..|:.:.|.|:|.|:.....::|:|....::|:.:|...
Human   159 K-----QSNGSIVVVSSLAG----KVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCV 214

  Fly   194 PGMVDTDFLSVYSQAVAELPKLQA 217
            .|::||:   ...:||:.:..:||
Human   215 LGLIDTE---TAMKAVSGIVHMQA 235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rdhB	NP_001262831.1	Mgc4172-like_SDR_c	4..244	CDD:187601	57/219 (26%)
		YdfG	9..241	CDD:226674	57/218 (26%)
HSD11B1	NP_001193670.1	11beta-HSD1_like_SDR_c	32..279	CDD:187593	57/219 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810