Protein Alignment CG7084 and SLC22A8

DIOPT Version :10

• Sequence 1: NP_651016.1
• Gene: CG7084 / 42606
• FlyBaseID: FBgn0038938
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_004245.2
• Gene: SLC22A8 / 9376
• HGNCID: 10972
• Length: 542
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 132/558 - (23%)
• Similarity: 244/558 - (43%)
• Gaps: 53/558 - (9%)

  Fly    34 FQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNI--ILALNIPDHWCTVPGRENTNFSLEEW 96
            |..::::.|:.|.:|.|:  |.:.||.... |...|:  |.....|.|.|..|    .|.|...|
Human     3 FSEILDRVGSMGHFQFLH--VAILGLPILN-MANHNLLQIFTAATPVHHCRPP----HNASTGPW 60

  Fly    97 RDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTKTTEACQNGWSYDKTWYESTIPTD 161
               .||...:.:..:    |    :.|....:.|..| :..:..|.|.:||.|:.|  :.:|.|:
Human    61 ---VLPMGPNGKPER----C----LRFVHPPNASLPN-DTQRAMEPCLDGWVYNST--KDSIVTE 111

  Fly   162 HNWVC--------AKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSI 218
            .:.||        |:.:|:..:.:        |..:||.:.|.:|||.:...|.:..:....|:.
Human   112 WDLVCNSNKLKEMAQSIFMAGILI--------GGLVLGDLSDRFGRRPILTCSYLLLAASGSGAA 168

  Fly   219 MCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWL 283
            . :.::..:::...:.|..::.:..|..|:.:|......|:.::......::.|..::|.|.:.:
Human   169 F-SPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAI 232

  Fly   284 RHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGHRFDMTEKELAEI 348
            ..|.......|||..:..|.|.:..||.|||:...:..:|:..|:::|..||.:.:.....|.|:
Human   233 PQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEEL 297

  Fly   349 YSRDKQDVT-----YGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQ 408
            ....:::::     |..:.||....|.|.|..:..:|.....:|::|.:.......|.::..:..
Human   298 KLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIF 362

  Fly   409 SIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIYLATFIKFLNALT 473
            ..|::||..:........||..|.:.:.|::....|.:.....|  .:.:...||.|.|...:.:
Human   363 GGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLD--LQTVRTVLAVFGKGCLSSS 425

  Fly   474 FFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLFLLGGIGA 538
            |..:.|...|:|||.:||||:.:..:......:::| ||.:...|....|..|.|:..||||..|
Human   426 FSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSP-LVKITGEVQPFIPNIIYGITALLGGSAA 489

  Fly   539 LFLPETLHKKLPDTMEEAGHFGKHDKFFSLPKPPQAAE 576
            |||||||::.||:|:|:..::....|     ||.|..|
Human   490 LFLPETLNQPLPETIEDLENWSLRAK-----KPKQEPE 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_651016.1	MFS_SLC22	146..542	CDD:340875	92/408 (23%)
SLC22A8	NP_004245.2	2A0119	11..503	CDD:273328	124/524 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..542		5/13 (38%)