Protein Alignment CG7084 and SLC22A6

DIOPT Version :9

• Sequence 1: NP_001247235.2
• Gene: CG7084 / 42606
• FlyBaseID: FBgn0038938
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_004781.2
• Gene: SLC22A6 / 9356
• HGNCID: 10970
• Length: 563
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 151/595 - (25%)
• Similarity: 261/595 - (43%)
• Gaps: 82/595 - (13%)

  Fly    30 FNDPFQALMEKAGNHGRYQTL-YNFVFVGGLAFSGAMIYMNIILALNIPDHWCTVPGREN--TNF 91
            |||    |:::.|..||:|.: ...|.:..|..:......|...|  ||.|.|..|...|  .|.
Human     3 FND----LLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAA--IPTHHCRPPADANLSKNG 61

  Fly    92 SLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTKTTEACQNGWSYDKTWYES 156
            .||.|    ||:  |.:|:.  .:|..|......:...:...:|.|..||.|.:||.||.:.:.|
Human    62 GLEVW----LPR--DRQGQP--ESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPS 118

  Fly   157 TIPTDHNWVC--------AKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLG 213
            ||.|:.:.||        |:.|::..|.:        |:.:.|.:.|..|||.|..::.:..::
Human   119 TIVTEWDLVCSHRALRQLAQSLYMVGVLL--------GAMVFGYLADRLGRRKVLILNYLQTAV- 174

  Fly   214 RLGSIMCTS------SYTWFLIMSG--IVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWS 270
               |..|.:      .|..|.::||  :.|:::|.:     .:.:|......|:.:.......:|
Human   175 ---SGTCAAFAPNFPIYCAFRLLSGMALAGISLNCM-----TLNVEWMPIHTRACVGTLIGYVYS 231

  Fly   271 IGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKING 335
            :|..|:..:.:.:.||.....|.|.|.....::|.:.|||.||..|..|....:..||::|:|||
Human   232 LGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARING 296

  Fly   336 HRFDMTEKELAEIYSRDKQDVTYGIASLFAGWRLARNTTI------MGFSWCVVAVSYFTLVLFS 394
            .|.:..:..:..:.:..::::|.|.....| ..|.|..|:      :...|...:.:|:.||:..
Human   297 KREEGAKLSMEVLRASLQKELTMGKGQASA-MELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL 360

  Fly   395 SRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLM 459
            .....:.:|..:....|::||.:||..:.::.|||.....:.|::.:..|...|...|:..  :.
Human   361 QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSI--VR 423

  Fly   460 IYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPY 524
            ..||...|...|.:|..:.|...|:|||.:||||:.:|:.:|....:::| ||.:...:....|.
Human   424 TSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSP-LVSMTAELYPSMPL 487

  Fly   525 YILGVLFLLGGIGALFLPETLHKKLPDTME-----------EAGHF---GK-------HDKFFSL 568
            :|.|.:.:......:.|||||.:.||||::           |||.:   ||       |.|:. :
Human   488 FIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYM-V 551

  Fly   569 PKPPQAAEKD 578
            |....|.||:
Human   552 PLQASAQEKN 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	128/511 (25%)
		MFS	184..542	CDD:119392	85/371 (23%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	134/534 (25%)
		MFS	135..505	CDD:119392	88/390 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..563		11/38 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020