DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	140/565 - (24%)
Similarity:	253/565 - (44%)	Gaps:	63/565 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FQALMEKAGNHGRYQTLYNFVF---VGGLAFSGAMIYMNIILALNIPDHWCTVPGRENTNFSLEE 95
            |..::::.|:.|.:|.|:..:.   |.|:|....:    .|.....|.|.|..|    .|.|:..
  Rat     3 FSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLL----QIFTATTPVHHCRPP----PNASIGP 59

  Fly    96 WRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTKTTEACQNGWSYDKTWYESTIPT 160
            |   .||...:.:..|    |    :.|..:.:.|..| :..:.||.|.:||.|:.|  ..||..
  Rat    60 W---VLPLDPNGKPEK----C----LRFVHLPNASLPN-DTQRATEPCLDGWIYNST--RDTIVI 110

  Fly   161 DHNWVC--------AKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGS 217
            :.:.||        |:.:|:..:.|        |..::|::.|.:||:.:...|.:..:....|:
  Rat   111 EWDLVCSSNKLKEMAQSIFMAGILV--------GGPVIGELSDRFGRKPILTWSYLMLAASGSGA 167

  Fly   218 IMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGME----ISREEDRSRIAFFQSCGWSIGTTLMPL 278
            .. :.|...::|...:.|.:::.:..|..|:.:|    ..|....:.|.:   | ::||..::..
  Rat   168 AF-SPSLPVYMIFRFLCGCSISGISLSTVILNVEWVPTSMRAISSTSIGY---C-YTIGQFILSG 227

  Fly   279 LYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGHRFDMTEK 343
            |.:.:..|......:|.|..:..|.|.:|.||.|||:...::.:|:..||::|..||.:.:..:.
  Rat   228 LAYAIPQWRWLQLTSSAPFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKKEEGKKL 292

  Fly   344 ELAEIYSRDKQDVT-----YGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFL 403
            .:.|:....::|:|     ||::.||....|.|.|..:..:|.....:|::|.:.......|.::
  Rat   293 TIEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYI 357

  Fly   404 NFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIYLATFIKF 468
            ..:....|:|||..:........|||.|.|...|::....|.:|...::  .:.|...||.|.|.
  Rat   358 LQIIFGGVDIPAKFITILSLSYLGRRITQSFLLLLAGGAILALIFVPSE--MQLLRTALAVFGKG 420

  Fly   469 LNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLFLL 533
            ..:.:|..:.|...|:|||.:||||:.:..:.|....::|| ||.:...:....|..|.|...||
  Rat   421 CLSGSFSCLFLYTSELYPTVLRQTGMGISNVWARVGSMIAP-LVKITGELQPFIPNVIFGTTALL 484

  Fly   534 GGIGALFLPETLHKKLPDTMEEAGHFGKHDKFFSLPKPPQAAEKD 578
            ||..|.||.|||::.||:|:|:..::.|     .:.|..|.:|.:
  Rat   485 GGSAAFFLLETLNRPLPETIEDIQNWHK-----QVQKTKQESEAE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	126/504 (25%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	91/366 (25%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	133/529 (25%)
		MFS	124..492	CDD:119392	93/383 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536		3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020