DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and SLC22A4

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_003050.2	Gene:	SLC22A4 / 6583	HGNCID:	10968	Length:	551	Species:	Homo sapiens

Alignment Length:	544	Identity:	163/544 - (29%)
Similarity:	270/544 - (49%)	Gaps:	64/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GNHGRYQTLYNFVFVGGL---AFSGAMIYMNIILALNIPDHWCTVPGRENTNFSLEEWRDITLPK 103
            |..|.:|.|..|:....:   .|:|    |:::.....|:|.|.||...|.:   ..||:.::|.
Human    12 GEWGPFQRLIFFLLSASIIPNGFNG----MSVVFLAGTPEHRCRVPDAANLS---SAWRNNSVPL 69

  Fly   104 QADNRGRKTFSNCEMFQM----NFSEITDWSAWNSNLTK-TTEACQNGWSYDKTWYESTIPTDHN 163
            :..: ||:...:|..:::    |||.:......:.:|.: ..|:|.:||.:.:..|.||:.|:.|
Human    70 RLRD-GREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWN 133

  Fly   164 WVCA---KDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLG-RLG-SIMCTSS 223
            .||.   |....|::|.||   .:.|||:.||:.|.:||:     :|:|.::. :.| |.:...|
Human   134 LVCEDNWKVPLTTSLFFVG---VLLGSFVSGQLSDRFGRK-----NVLFATMAVQTGFSFLQIFS 190

  Fly   224 YTW--FLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCG----WSIGTTLMPLLYWW 282
            .:|  |.::..|||:...|.:....|:|.||..:..|   ..|.:.|    :::|..|:||..::
Human   191 ISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVR---IIFSTLGVCTFFAVGYMLLPLFAYF 252

  Fly   283 LRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGHR-----FDMTE 342
            :|.|...:...::|..:.:....::.||||||||::|||||...:||.||:|...     ||..|
Human   253 IRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVE 317

  Fly   343 KELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLY 407
             ||..:    ||...: |..||....:|..|.:....|.:.:|.||.|.|.:..:.|:.:||...
Human   318 -ELNPL----KQQKAF-ILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFL 376

  Fly   408 QSIVEIPAYVVGRYMGDTYGRRF-TNSVSF----LISFVTCLPIIVYSTDERYENLMIYLATFIK 467
            .:::|||||:....:..|..||: ..:|.|    ::.|:..:|:..|.       |.|.|....|
Human   377 SALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYF-------LSIGLVMLGK 434

  Fly   468 FLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIG-VLAPYLVYLGTTVDIRAPYYILGVLF 531
            |.....|..:.:...|:|||.:|...|.: |..|:.:| ::|||.|||| ..:...||.::|.|.
Human   435 FGITSAFSMLYVFTAELYPTLVRNMAVGV-TSTASRVGSIIAPYFVYLG-AYNRMLPYIVMGSLT 497

  Fly   532 LLGGIGALFLPETLHKKLPDTMEE 555
            :|.||..||.||:|...||:|:|:
Human   498 VLIGILTLFFPESLGMTLPETLEQ 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	154/514 (30%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	116/376 (31%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	161/539 (30%)
SLC22A4	NP_003050.2	MFS	123..508	CDD:119392	128/410 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.030