Protein Alignment CG7084 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_651016.1
• Gene: CG7084 / 42606
• FlyBaseID: FBgn0038938
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 138/553 - (24%)
• Similarity: 254/553 - (45%)
• Gaps: 46/553 - (8%)

  Fly    34 FQALMEKAGNHGRYQ-TLYNFVFVGGLAFSGAMIYMNIILALNIPDH-WCTVPG----RENTNFS 92
            |...:::.|..||:| .::..:.:.|:.|  |.:::.::.....||| ||..|.    .|...:|
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTF--AFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWS 66

  Fly    93 LEEWRDITL-----PKQADNRGRKTFSNCEMFQMNFS----------EITDWSAWNSNLTKTTEA 142
            .||..:.|.     |:..:.|||     |:.:.:..:          ...|..|...|.:.....
Human    67 PEEEWNRTAPASRGPEPPERRGR-----CQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVP 126

  Fly   143 CQNGWSYDKTWYESTIPTDHNWVCAKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISV 207
            |:.||.|.:.  .|||.::.:.||.....:.....:..:..:.|:|.||...|.|||..:|.:|.
Human   127 CRGGWRYAQA--HSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSC 189

  Fly   208 VFCSLGRLGSIMC-TSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSI 271
            :  .:|..|.::. ..::..|:|...:.|:.....:.:..:|..||...:.|..:.......:::
Human   190 L--GVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTL 252

  Fly   272 GTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGH 336
            |..::|.:.:::.:|.......::|:.:.||:...|.|||||||::::..:|:..|::|||.||
Human   253 GIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNG- 316

  Fly   337 RFDMTEKELAEIYSR----DKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRM 397
                  |.|:..||.    |::........|....::.:.|.|:.|:|...||.|..||:....:
Human   317 ------KYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGII 375

  Fly   398 AGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIYL 462
            .||.:::|....:||:|..::.....:..|||...:.|.:::.|.||  :.....|....|...:
Human   376 GGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACL--VTAFLPEGIAWLRTTV 438

  Fly   463 ATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYIL 527
            ||..:....:.|..|.|...|:|||.:|..||:|.:.|.:..|::||:|::....|.:..|..|.
Human   439 ATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIF 503

  Fly   528 GVLFLLGGIGALFLPETLHKKLPDTMEEAGHFG 560
            |:|..:.|...:.||||....||:|:::....|
Human   504 GILASICGGLVMLLPETKGIALPETVDDVEKLG 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_651016.1	MFS_SLC22	146..542	CDD:340875	102/400 (26%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	135/535 (25%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		2/3 (67%)