DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and SLC22A23

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_011513103.1	Gene:	SLC22A23 / 63027	HGNCID:	21106	Length:	710	Species:	Homo sapiens

Alignment Length:	685	Identity:	149/685 - (21%)
Similarity:	241/685 - (35%)	Gaps:	200/685 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 MDVDDSEFNDPFQALMEKAGNHGRYQ------TLYNFVFVGGLAFSGAMIYMNIILALNIPDHWC 81
            :|.|.|..  ||     ..|..|.||      |....:|:|...||.:.:       |:.|:.||
Human    78 LDYDGSVL--PF-----LGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFL-------LDQPNFWC 128

  Fly    82 ------------TVPGR----------ENTNFSLEEWRDI------------------TLPKQAD 106
                        |..||          ..|.|:...|...                  :.|.:.|
Human   129 RGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGD 193

  Fly   107 NRGRKTFSNCEMFQMNFSEITDWSAWNSNL------TKTTEACQN------GWSYD-KTWYESTI 158
            |.     |||           |..||:..:      ...::.||.      .|..| |.|
Human   194 NA-----SNC-----------DCRAWDYGIRAGLVQNVVSKCCQQQETGALPWDTDTKRW----- 237

  Fly   159 PTDHNWVCAKDLFVTNVFVVG------RVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGS 217
            ..:.||    ||...|.:.|.      .|..:.|..|.|.:.|..|||.|...|::|..:..| :
Human   238 RPELNW----DLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGL-T 297

  Fly   218 IMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMPLLYWW 282
            :..:.:.|.|..:....|..:..:..:...:.:|:.....|..|....|.....|..|||.|...
Human   298 VALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAAL 362

  Fly   283 LRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREA---IVQLQKIAKINGHR-----FD 339
            .|.|.....|...|..::||:.....||.|||::.|:|..|   |:...:..::|...     ..
Human   363 CRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIP 427

  Fly   340 MTEKELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVS-YFTLVLFSSRMAGNPFL 403
            ..||||    ||..:.|.  |..:.....|.:|..::    ||.::: |.....|:..|.|:.
Human   428 ELEKEL----SRRPKKVC--IVKVVGTRNLWKNIVVL----CVNSLTGYGIHHCFARSMMGHE-- 480

  Fly   404 NFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPI-IVYSTDERYENLMIY-----L 462
                   |::|  ::..:..|.|       .:..|:.|:||.: :|.....|...|:::     |
Human   481 -------VKVP--LLENFYADYY-------TTASIALVSCLAMCVVVRFLGRRGGLLLFMILTAL 529

  Fly   463 ATFIK--FLN---------------------ALTFFTVNL------------QCLEIYPTCMRQT 492
            |:.::  .||                     ::.|..|.:            .|.||.||.:|..
Human   530 ASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCG 594

  Fly   493 GVALGTILANA-IGVLAPYLVYLGTTVDIRAPYYILGVLF----LLGGIGALFLPETLHKKLPDT 552
            |  ||.:||:| .|:|...::.|..    :..|::..::|    |:..|..|.|||:..:.||:.
Human   595 G--LGLVLASAGFGMLTAPIIELHN----QKGYFLHHIIFACCTLICIICILLLPESRDQNLPEN 653

  Fly   553 MEEAGHFGKHDKFFSLPKPPQAAEKDDKLSSHPEL 587
            :....|:.:.      |..|....:...|.::.||
Human   654 ISNGEHYTRQ------PLLPHKKGEQPLLLTNAEL 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	129/601 (21%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	92/412 (22%)
SLC22A23	XP_011513103.1	2A0119	<243..652	CDD:273328	102/447 (23%)
SLC22A23	XP_011513103.1	MFS	259..>388	CDD:119392	30/129 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100