DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7084 and slc22a4

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_989323.1	Gene:	slc22a4 / 394948	XenbaseID:	XB-GENE-5858686	Length:	553	Species:	Xenopus tropicalis

Alignment Length:	540	Identity:	167/540 - (30%)
Similarity:	276/540 - (51%)	Gaps:	58/540 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GNHGRYQTLYNFVFVGGL---AFSGAMIYMNIILALNIPDHWCTVPGRENTNFSLEEWRDITLPK 103
            |..||||.:..|:....:   .|:|    |:::....||:|.|.:|  |:.|.| ..||:.::|:
Frog    12 GEWGRYQFMIFFLLSASIIPNGFNG----MSVMFLAGIPEHRCHIP--ESANLS-AAWRNASIPR 69

  Fly   104 QADNRGRKTFSNCEMFQMNFSEITDWSAW------NSNLTK-TTEACQNGWSYDKTWYESTIPTD 161
            | |.:.    |.|..:::  ..:|::||.      :.::|. ..|.|.:||:|.|:.|.|||.|:
Frog    70 Q-DGQD----SQCRRYRL--GTLTNYSALGLLPGRDVDVTGIEQEPCLDGWNYSKSLYLSTIVTE 127

  Fly   162 HNWVCAKDL---FVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLG-SIMCTS 222
            .:.||..|.   ..|::|.||   .:.|||:.||:.||:||:.:.::::..    :.| ||:...
Frog   128 WDIVCENDWKGPLTTSLFFVG---VLLGSFVSGQLSDSFGRKKILFVTMAI----QTGFSIVQVF 185

  Fly   223 SYTW--FLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSC-GWSIGTTLMPLLYWWLR 284
            |.:|  |.|:..|||:...|.:.:..|:|.||..:..|...:...:| .::||..::||..:::|
Frog   186 STSWEMFAILFLIVGMGQISNYVAAFILGTEILGKSARIIFSTLGTCIFFAIGYMMLPLFAYFIR 250

  Fly   285 HWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKIN-----GHRFDMTEKE 344
            .|.:.:...:||....:.....:.|||:|||.|.|..||.|.::|.||||     ...|..|  |
Frog   251 DWRTLLLALTIPGLFCIPLWWIIPESPQWLICKGRLEEAEVIIRKAAKINRVPAPAVIFKTT--E 313

  Fly   345 LAEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQS 409
            |.:|..|.|:  :|.:..|...:.:...|.:..|.|.:.::.||.:.|.:..:.|:||||....:
Frog   314 LEDIAERQKR--SYTLLDLVKTFNVRIITIMTVFLWLITSIGYFGISLNTPNLHGDPFLNCFLLA 376

  Fly   410 IVEIP----AYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIYLATFIKFLN 470
            .:|:|    |:::.||:    .||::...|.|:..|..|.|.:...|  .:.|...|....||..
Frog   377 AIEVPSNIFAWLLLRYI----SRRYSMCGSLLLGGVVLLLIQLVPLD--LQILSTVLVMVGKFGV 435

  Fly   471 ALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLFLLGG 535
            ...|..|.:...|:|||.:|.|||.:|::.:....|::||.|||| ..:...||.::|.|.:..|
Frog   436 TAAFSMVYVYTAELYPTVIRNTGVGIGSVSSRIGSVISPYFVYLG-AYNRLLPYILMGSLTVANG 499

  Fly   536 IGALFLPETLHKKLPDTMEE 555
            |..||.|||..|.||:|:|:
Frog   500 ILVLFFPETFGKPLPETIEQ 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	157/510 (31%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	113/370 (31%)
slc22a4	NP_989323.1	2A0119	12..516	CDD:273328	165/535 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110