DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7084 and slc22a4

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	569	Identity:	156/569 - (27%)
Similarity:	265/569 - (46%)	Gaps:	66/569 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GNHGRYQTLYNFVFVGGLAFS---GAMIYMNIILALNIPDHWCTVPGRENTNFSLEEWRDITLPK 103
            |..|.:|..   ||: .||.|   ...:.:.|:...:.|.|.|.:|  |..|.| ..|||..:|.
Zfish    12 GTWGPFQLT---VFL-ALAISILPNGFVGLYIVFVGDTPAHECLIP--EQINIS-SVWRDAAIPT 69

  Fly   104 QADNRGRKTFSNCEMFQMNFSEITDWSAWN------SNLTK-TTEACQNGWSYDKTWYESTIPTD 161
            |..: |....|:|..::::  .:...|..|      .||:: .||.|.:||||.:.:|:|||.|:
Zfish    70 QMQD-GVLKRSSCSRYRLD--TLRQLSMLNYTPNVEVNLSQIETEPCVDGWSYSQEFYQSTIVTE 131

  Fly   162 HNWVCAKDL---FVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSIMCTSS 223
            .:.||.::.   ..::::..|   .:.|:|:.|||.|.||||.|.:..:...::..|.. |.:.|
Zfish   132 WDLVCEREYKGPLTSSIYFCG---VLVGTFLSGQMSDRYGRRPVLFTMMALQTITILIQ-MFSPS 192

  Fly   224 YTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAF-----FQSCGWSIGTTLMPLLYWWL 283
            :..|..:...||.:..|.:....::|.||.  ...||:.|     |...|  ||....||..:::
Zfish   193 WEVFSAIYFFVGFSGFSNYVVAYVLGSEIL--SPASRVLFGSLGVFMGSG--IGQMFFPLAAYFI 253

  Fly   284 RHWDSFMWLTSIPTAMVLLFSK---YVIESPRWLISKQRFREAIVQLQKIAKINGHRFDMTEKEL 345
            |.|   .||........||:..   ::.||||||:|:.|..||...|::.|:.|    .:|..|:
Zfish   254 RSW---RWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKN----RVTAPEV 311

  Fly   346 ----AEIYSRDKQDV-TYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNF 405
                :||....|:.: .:.|..:.:.........|....|.|:.:||:.|:|.::.:.|||:|||
Zfish   312 IFSSSEIEEAAKKRIQKHSILDILSNCNAVSTILICSLLWMVITMSYYALILNTTNLHGNPYLNF 376

  Fly   406 LYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIYLATFIKFLN 470
            ...::||:|||::...:.....||...:.:.|:.......|.:..|:      :..|||.::.|.
Zfish   377 FLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPTE------LQGLATALEMLG 435

  Fly   471 AL----TFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLF 531
            .|    .|..|.....|::||.:|...:...::.|....:::|:::|||..... .||.::|.|.
Zfish   436 KLCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYYRY-IPYIVIGGLA 499

  Fly   532 LLGGIGALFLPETLHKKLPDTMEEAGHFGKHDKFFSLPKPPQAAEKDDK 580
            |..|:.:|.|||:..|.||:|:.:.    :..:.....:.|.||..:||
Zfish   500 LFSGVMSLLLPESKGKVLPETIAQM----QSVRGLRRCRKPPAASTEDK 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	142/514 (28%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	101/374 (27%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	150/539 (28%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	102/387 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.030