DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and SLC22A10

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001034841.3	Gene:	SLC22A10 / 387775	HGNCID:	18057	Length:	541	Species:	Homo sapiens

Alignment Length:	575	Identity:	142/575 - (24%)
Similarity:	246/575 - (42%)	Gaps:	83/575 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNIILALN----IPDHWC--------TVPGR 86
            |:.|:.:.|..||:|.|: .||:    ....|:.:..||..|    ||.|.|        |..|.
Human     3 FEELLSQVGGLGRFQMLH-LVFI----LPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGSGN 62

  Fly    87 ENTNFSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLT------KTTEACQN 145
            |....|.:....|::|..::.|..|    |..|..     ..|...:.|.|      ..||.|.:
Human    63 ETGILSEDALLRISIPLDSNLRPEK----CRRFVH-----PQWQLLHLNGTIHSTSEADTEPCVD 118

  Fly   146 GWSYDKTWYESTIPTDHNWVC--------AKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFV 202
            ||.||::::.|||.|..:.||        .:.|.:|.:.|        |..|.|.:.|.:||||:
Human   119 GWVYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLV--------GGIIGGHVSDRFGRRFI 175

  Fly   203 YYISVVFCSLGRLGSIMCTS---SYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFF 264
                :.:|.|....:..|.:   ::..:.::..:.|.:...:..:..:...|..|...::.:...
Human   176 ----LRWCLLQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVIL 236

  Fly   265 QSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQK 329
            .|...|||..::..|.:..|.|.:...:.|:|..:..|.|::::||.||||...:..|.:..|:|
Human   237 SSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRK 301

  Fly   330 IAKINGHR-------FDMTEKELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSY 387
            :|:.||.:       .::....:.|  ..|.......:..||....:.:...|:.|......:.:
Human   302 VARTNGIKNAEETLNIEVVRSTMQE--ELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPF 364

  Fly   388 FTLVLFSSRMAGNPF-LNFLYQS---IVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIV 448
            :..::....:..|.| |..||.:   ||...|.:...:|    |||.:   ..|..|:..|.|:.
Human   365 YGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHM----GRRIS---QILFMFLVGLSILA 422

  Fly   449 YS-TDERYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCM--RQTGVALGTILANAIG-VLAP 509
            .: ..:..:.|.:.||......:|.||.:|.:..:|:.||.:  |.:|:.|   .|:.|| .|||
Human   423 NTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDL---TASRIGAALAP 484

  Fly   510 YLVYLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEEAGHFGKHDK 564
            .|:.| |......|:.|.|:..::||:....||||.:..||||:::..:..|:.|
Human   485 LLMTL-TVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLK 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	129/531 (24%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	86/375 (23%)
SLC22A10	NP_001034841.3	2A0119	11..526	CDD:273328	136/553 (25%)
SLC22A10	NP_001034841.3	MFS	143..516	CDD:119392	89/397 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010