DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7084 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001032838.1	Gene:	Slc22a14 / 382113	MGIID:	2685974	Length:	629	Species:	Mus musculus

Alignment Length:	559	Identity:	123/559 - (22%)
Similarity:	228/559 - (40%)	Gaps:	77/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DSEFNDPFQALMEKAGNHGRYQ-TLYNFVFVGGLAFSGAMIYMNIILALNIPDHWCTVPGRENTN 90
            |:..:|.|.::|:..|..|.:| .|....|:..:..:..:...:.:|....|  :|      ||:
Mouse    44 DARRDDKFASVMDAIGEFGTFQWRLVVLTFIPSILSTFFIFSHHFLLTAQRP--YC------NTS 100

  Fly    91 FSLE--------EWRDITLPKQADNRGRKTFSNCEM-------------FQMNFSEITDWSAWNS 134
            :.||        |..::|||:..:.    :|..|.|             |.:|:
Mouse   101 WILEVGPNLTEDEQLNLTLPRAPNG----SFLTCLMYIPVPWDLDSIIHFGLNY----------- 150

  Fly   135 NLTKTTEACQNGWSYDKTWYESTIPTDHNWVCAKDLFVTN---VFVVGRVTEVAGSFILGQMGDS 196
                 ||.|:.||.|......|.| .:.:.||..:....|   ||:.|.:|   ||.:.|.:.|.
Mouse   151 -----TETCKFGWIYPFAHTRSLI-NEFDLVCGNEPNKENGLTVFLSGVLT---GSLLFGFLSDK 206

  Fly   197 YGRRFVYYISVVFCSLGRLGSIMCTSSYTW----FLIMSGIVGLTVNSLFQSPQIIGMEISREED 257
            .||..:..:|::...:...|:...:|.|.:    |.:....||..:.|:     .:.||....|.
Mouse   207 LGRYPIILLSLLGFLIFGFGTAFVSSFYQYLFFRFFVAQASVGYAICSV-----SLVMEWLVGEH 266

  Fly   258 RSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVI-ESPRWLISKQRFR 321
            |::....|....:||..|:..|.:.:.||.....|..:| ...|:.:.:|: ||||||:.:.:..
Mouse   267 RAQAVILQHSFLTIGVILLTGLAYKVVHWRLLCLLGGMP-MFPLICNIWVLRESPRWLMVRGKVE 330

  Fly   322 EAIVQLQKIAKINGHRFDMTEKELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVS 386
            ||...|...|::|.....:  ..|.|:....|:.....|........|.:....:|..|..|:..
Mouse   331 EAKKVLCYAAEVNKKTIPL--NLLNELQISGKKVAKASILDFCTNQHLFKVVLAIGCVWFTVSYI 393

  Fly   387 YFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYST 451
            .|||.|..:....:.:...:.:|||.:||.:....:.:.:||::..:::..:....||.::....
Mouse   394 SFTLNLKMNDFGLDVYFVQMVRSIVAVPARLCCIILLEYFGRKWALNLTLFLVTSMCLFLLFLPQ 458

  Fly   452 DERYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTI-LANAIGVLAPYLVYLG 515
            :.:...::..:.........|:.|.:  ...|:.||.:|.||  ||.: ||...|.::...::..
Mouse   459 EPKSTIILTLMLAEFSMAGTLSIFFI--YTAELLPTVLRSTG--LGMVSLAWVAGAISSVAIFKQ 519

  Fly   516 TTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTME 554
            |...:  |.:...:..:|....:..:|||..:.|.|::|
Mouse   520 TKTQL--PIFFCCLCCVLALCFSSLVPETGSQSLRDSIE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	112/517 (22%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	77/363 (21%)
Slc22a14	NP_001032838.1	2A0119	59..553	CDD:273328	117/539 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100