DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	142/583 - (24%)
Similarity:	242/583 - (41%)	Gaps:	92/583 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNII--LALNIPDHWCTVPGRENT------- 89
            |..|:::.|..||:|.|.....|..:.:   :...|::  .:..:|.|.|.||..:|:
  Rat     3 FPELLDRVGGRGRFQLLQAVALVTPILW---VTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIP 64

  Fly    90 -NFSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTKT------TEACQNGW 147
             :|..:....:::|...|.|..:    |..|:.     ..|....||.|.|      ||.|::||
  Rat    65 GDFGRDVLLAVSIPPGPDQRPHQ----CLRFRQ-----PQWQLIESNTTATNWSDADTEPCEDGW 120

  Fly   148 SYDKTWYESTIPTDHNWVC--------AKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYY 204
            .||.:.:.|||.|..:.||        |:.:|:..:.|        |:.:.|...|.:|||.|..
  Rat   121 VYDHSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILV--------GAAVCGHASDRFGRRRVLT 177

  Fly   205 ISVVFCSL-GRLGSIMCTSSYTW---FLIMSGIVGLTVN--SLFQSPQIIG-------------- 249
            .|.:..|: |.:.::|.|.....   ||:.|.:.|:.:|  ||...|.::|
  Rat   178 WSYLLVSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTASLCMFPVVLGREGYMQDPELTPSL 242

  Fly   250 ----MEISREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIES 310
                ||.:..:....:....:.|:|.|..|...:.:.:|.|.......|.|..:..::|.::.||
  Rat   243 LLAVMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPES 307

  Fly   311 PRWLISKQRFREAIVQLQKIAKINGHRFDMTEKELAEIYSRDKQDVTYGIASLFAGWRLAR---- 371
            .||||:..|..:::.:||::|.:|..:.: .:....|:.....|:...|..   ||.||..
  Rat   308 ARWLITVGRLDQSLRELQRVAAVNRRKAE-ADTLTVEVLRSAMQEEPNGNQ---AGARLGTLLHT 368

  Fly   372 -----NTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFT 431
                 .|.|....|.....:::.|.|....:..|.||......||::|..:....:....|||..
  Rat   369 PGLRLRTFISMLCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLC 433

  Fly   432 NSVSFLISFVTCLPIIVYSTDERYENLMIYLATFIKFLN----ALTFFTVNLQCLEIYPTCMRQT 492
            .:.|.::..:..|..|:...:      |..|.:.:..|.    ...|..|.:...|::||.:|.|
  Rat   434 QASSLVLPGLCILANILVPRE------MGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMT 492

  Fly   493 GVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEE 555
            .|.||.:.|....:|.|.:..|| ......|..:.||:.:|.|:.||.||||.:..||||:::
  Rat   493 AVGLGQVAARGGAMLGPLVRLLG-VYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQD 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	132/548 (24%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	92/394 (23%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	108/450 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020