DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a30

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_795976.1	Gene:	Slc22a30 / 319800	MGIID:	2442750	Length:	552	Species:	Mus musculus

Alignment Length:	591	Identity:	147/591 - (24%)
Similarity:	256/591 - (43%)	Gaps:	95/591 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FQALMEKAGNHGRYQTL-YNFV-FVGGLA--------FSGAMIYMNIILALNIPDHWCTVPGREN 88
            ||.|:.:.|:.||:|.| .:|| |:.||.        |:.|           ||:|.|..|..:|
Mouse     3 FQELLNQVGSLGRFQILQISFVLFLVGLVVPHITMENFTAA-----------IPNHRCWAPILDN 56

  Fly    89 TN--------FSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTK-TTEACQ 144
            ..        .|.::...|::|..::.|    ...|..|......:...:...||.|: .||.|.
Mouse    57 DTASDNGSRILSQDDLLRISIPLDSNLR----LDKCRRFAQPQWHLLHLNGTFSNETEPDTEPCV 117

  Fly   145 NGWSYDKTWYESTIPTDHNWVC--------AKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRF 201
            :||.||::.:.|||.|:.:.||        ||..|:..:|:        |:.|.|.:.|.:||:|
Mouse   118 DGWVYDRSNFLSTIVTEWDLVCESQALNSVAKFSFMIGLFI--------GAIICGHLSDRFGRKF 174

  Fly   202 VYYISVVFCSLGRLG----SIMCTSSYTWFLIMSGIVGLTVNSL----------FQSPQIIGMEI 252
                 ::.|:|.:..    .:....|:..:.::..:.|::|..:          :.||:.:||
Mouse   175 -----ILTCALLQFAITETCVAFAPSFFIYCLLRFLAGMSVEPISVNSHLLMLEWTSPKFLGM-- 232

  Fly   253 SREEDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISK 317
                    :|...||..|||..::..|.:..|.|.......|:|....|:.::::.||.||||..
Mouse   233 --------VAVLTSCAASIGYMILAGLAFLFRIWRHLQLAMSVPIFFFLILTRWMSESARWLIVT 289

  Fly   318 QRFREAIVQLQKIAKING--HRFDMTEKELAEIYSRDKQDVTYGIAS---LFAGWRLARNTTIMG 377
            .:.::.:.:|:|:|.:||  :..:....|:.|...:::.:.....:|   ||....|.:...::.
Mouse   290 NKPQKGLKELRKVAHMNGMKNSGNTLTMEVVEASMKNELEAAKRKSSPRDLFHTPILRKRICVLS 354

  Fly   378 FSWCVVAVSYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVT 442
            |...:..:|.|.|.|....::.|..|.....|.:.|...|:|.::.:..|||.|..|  |:|...
Mouse   355 FMRYLFTISIFGLSLHLQHLSTNIILLQFLSSALGILISVIGHFVLNHMGRRITQLV--LMSLRG 417

  Fly   443 CLPIIVYSTDERYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVL 507
            ...:......:..:.|.|.:||....|::|.....||...|:.||.:|.||:.:..:..|:...|
Mouse   418 IFMLTAVFVPQEMQTLRIIMATLAAALSSLCMCVSNLHINELLPTTLRATGMGVIAMFGNSGLFL 482

  Fly   508 APYLVYLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEEAGHFGKHDKFFSLPKPP 572
            ||..:.| .|.....|:...|...:|.|.....||||.::.|||::.:.|:..|..:
Mouse   483 APLFMLL-ATYSANLPWIFYGGFSILYGFSVFLLPETKNQPLPDSIHDVGNDWKESR-------- 538

  Fly   573 QAAEKD 578
            ||.|:|
Mouse   539 QAKEED 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	126/523 (24%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	87/376 (23%)
Slc22a30	NP_795976.1	2A0119	11..525	CDD:273328	136/554 (25%)
Slc22a30	NP_795976.1	MFS	151..516	CDD:119392	89/390 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010