DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001013969.1	Gene:	Slc22a22 / 299944	RGDID:	1304605	Length:	555	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	132/565 - (23%)
Similarity:	255/565 - (45%)	Gaps:	81/565 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FQALMEKAGNHGRYQTLYNFVFVGGLAFSGAM--IYMNIILALNIPDHWCTVPGRENT------- 89
            |..::...|:.||:| ::..|.:..|:...::  :..|...|  ||.|.|:|...:.:
  Rat     3 FDEILHHVGDRGRFQ-IWMIVVLNILSMVSSLHDVIENFTAA--IPAHHCSVNLLDTSRSEISMA 64

  Fly    90 -NFSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTK-TTEACQNGWSYDKT 152
             |.:.|....:::|...:.:..:    |..|:....:..|.:...||.|: .||.|.:||:||.:
  Rat    65 MNLTTEAMMKVSIPMGPNQKPEQ----CRRFRHPQWQFIDSNISTSNSTELETEPCLDGWTYDHS 125

  Fly   153 WYESTIPTDHNWVCAKDLFVTNVFVVGRVTEVAGSFI----LGQMGDSYGRRFVYYISVVFCSL- 212
            .:.|||.|:.:.||....|.    ...:.|.:||.|:    .|.:.|.:||:.:    :::|||
  Rat   126 VFTSTIVTEWDLVCDFQSFK----YYAQATSLAGHFVAAPFCGIISDRFGRKPL----LMYCSLA 182

  Fly   213 -GRLGSIMCTS---SYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGT 273
             |.||:  |.:   :::.:.::..:...:.:::..:..|:.:|.:..:..:.:........|.|.
  Rat   183 YGILGT--CCAFVPNFSLYCVLRFLSSASASTVGMNCLILVLEETSVQWHATVIVLSGLFSSTGL 245

  Fly   274 TLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGHRF 338
            ..:..|.:.|..|......:::|..:..:...:|.||.|||:...:..:|:.:||:||.|||
  Rat   246 AGLGGLAYVLSDWHLIQLTSALPYFIFFILFCWVPESARWLMITGKTDQALKELQRIASING--- 307

  Fly   339 DMTEKELA------EIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAV------SYFTLV 391
               :|::|      ::.|:.|:||...:.. |:...:..|..|.....|..:|      |.|.|:
  Rat   308 ---KKDIAQNLTTEDLRSKVKEDVCSTVKH-FSIKDIIINPMIRKIVLCYSSVLFAELFSIFGLL 368

  Fly   392 LFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVT--CLPIIVYSTDER 454
            |....:..|.|:..:...:::||:..:..::.....||  ..::||: |.|  |:.|.::.:::.
  Rat   369 LDVHMLGKNIFVTQILLGVIDIPSKSLTYFILRNVRRR--PLIAFLL-FATGGCITITMFLSEDM 430

  Fly   455 YENLMIYLATFIKFLNAL-TFFTVN-LQCLEIYPTCMRQT--GV-----ALGTILANAIGVLAPY 510
            |   ::.||.||...... .|.::| ..|.|:.|..:|.|  |:     .|.::|:....|...|
  Rat   431 Y---VLRLAIFILGKGCFAAFISINTAYCNELSPVPLRSTLNGIYISVARLASVLSALTLVTRKY 492

  Fly   511 LVYLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEE 555
            .|.|        |....|||.::..|...|||||.:..:.||:::
  Rat   493 FVLL--------PMIFCGVLPIVATINIYFLPETFNHPITDTIKD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	123/530 (23%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	88/389 (23%)
Slc22a22	NP_001013969.1	2A0119	11..526	CDD:273328	129/552 (23%)
Slc22a22	NP_001013969.1	MFS	127..516	CDD:119392	96/419 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.100