DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	156/549 - (28%)
Similarity:	265/549 - (48%)	Gaps:	72/549 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GNHGRYQTLYNFVFVGGL---AFSGAMIYMNIILALNIPDHWCTVPGRENTNFSLEEWRDITLPK 103
            |..|.:|.|..|:....:   .|:|    |:|:.....|:|.|.||...|.:   ..||:.::|.
  Rat    12 GEWGPFQRLIFFLLSASIIPNGFNG----MSIVFLAGTPEHRCLVPHTVNLS---SAWRNHSIPL 69

  Fly   104 QADNRGRKTFSNCEMFQM----NFSEITDWSAWNSNLTK-TTEACQNGWSYDKTWYESTIPTDHN 163
            :..: ||:...:|..:::    |||.:......:.:|.: ..|.|.:||.|:|..:.|||.|:.:
  Rat    70 ETKD-GRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDVFLSTIVTEWD 133

  Fly   164 WVCAKDL---FVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLG--------RLGS 217
            .||..|.   ..|::|.||   .:.||||.||:.|.:||:     :|:|.::|        :|.|
  Rat   134 LVCKDDWKAPLTTSLFFVG---VLMGSFISGQLSDRFGRK-----NVLFLTMGMQTGFSFLQLFS 190

  Fly   218 IMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSC-GWSIGTTLMPLLYW 281
            :    ::..|.::..:||:...|.:.:..::|.||..:..|...|....| .::.|..::||..:
  Rat   191 V----NFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAY 251

  Fly   282 WLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKING-----HRFDMT 341
            ::|.|...:...::|..:......::.||||||||:.|.:||.|.::|.||.||     ..||
  Rat   252 FIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFD-- 314

  Fly   342 EKELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMG-FSWCVVAVSYFTLVLFSSRMAGNPFLNF 405
            ..||.::.|:..|  ::.|..| ...|..|..|||. ..|..::|.||.|.|.:..:.|:.::|.
  Rat   315 PSELQDLNSKKPQ--SHHIYDL-VRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNC 376

  Fly   406 LYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLIS-----FVTCLPIIVYSTDERYENLMIYLATF 465
            ...:.||:||||:...:.....||::.|.:..:.     |:..:|           :.:.||:|.
  Rat   377 FLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVP-----------SELFYLSTA 430

  Fly   466 I----KFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYI 526
            :    ||.....:..|.:...|:|||.:|..||.:.:..:....:|:||.|||| ..|...||.:
  Rat   431 LVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLG-AYDRFLPYIL 494

  Fly   527 LGVLFLLGGIGALFLPETLHKKLPDTMEE 555
            :|.|.:|..|..||.||:....||||:::
  Rat   495 MGSLTILTAILTLFFPESFGAPLPDTIDQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	147/519 (28%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	108/381 (28%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	154/544 (28%)
		MFS	123..510	CDD:119392	119/415 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D375160at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030