DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	138/555 - (24%)
Similarity:	253/555 - (45%)	Gaps:	68/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FNDPFQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNIILALNIPDHWCTVPGRENTNFS-- 92
            |||    |:::.|..||:|.:...:.|..|....:...:....|. ||.|.|..|.  |.|.|
  Rat     3 FND----LLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAA-IPPHHCRPPA--NANLSKD 60

  Fly    93 --LEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDW-----SAWNSNLTKTTEACQNGWSYD 150
              ||.|    ||  .|.:|:.  .:|..|..     ..|     :...:|.|:.||.|.:||.||
  Rat    61 GGLEAW----LP--LDKQGQP--ESCLRFTS-----PQWGPPFYNGTEANGTRVTEPCIDGWVYD 112

  Fly   151 KTWYESTIPTDHNWVCAKDLF---VTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSL 212
            .:.:.|||.|:.|.||:...|   ..::::||   .:.|:.:.|.:.|..|||.|..::.:..::
  Rat   113 NSTFPSTIVTEWNLVCSHRAFRQLAQSLYMVG---VLLGAMVFGYLADRLGRRKVLILNYLQTAV 174

  Fly   213 GRLGSIMCTS---SYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTT 274
                |..|.:   :||.:.:...:.|:::.|:..:...:.:|......|:.:.......:|:|..
  Rat   175 ----SGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQF 235

  Fly   275 LMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGHRFD 339
            |:..:.:.:.||.....:.|:|..:..::|.:.|||.||..|..|....:..||::|:|||.:.:
  Rat   236 LLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEE 300

  Fly   340 MTEKELAEIYSRDKQDVTY--GIASLFAGWRLARNTTI------MGFSWCVVAVSYFTLVLFSSR 396
            ..:..:..:.:..::::|.  |.||   ...|.|..|:      :...|...:.:|:.||:....
  Rat   301 GAKLSIEVLRTSLQKELTLSKGQAS---AMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQG 362

  Fly   397 MAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIY 461
            ...:.:|..:....|::||..|...:.::.|||.....|.|::.: |: ::.....:.:..:...
  Rat   363 FGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGI-CI-LVNGIIPKSHTIIRTS 425

  Fly   462 LATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYI 526
            ||...|...|.:|..:.|...|:|||.:||||:.:|:.:|....:::|       .|.:.|.:|.
  Rat   426 LAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSP-------LVSMTAEFYP 483

  Fly   527 LGVLFLLGGIGAL------FLPETLHKKLPDTMEE 555
            ...||:.|.:..:      .|||||.:.||||:::
  Rat   484 SMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	126/516 (24%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	81/374 (22%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	132/538 (25%)
		MFS	135..505	CDD:119392	83/388 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020