DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	145/547 - (26%)
Similarity:	259/547 - (47%)	Gaps:	39/547 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FQALMEKAGNHGRYQ-TLYNFVFVGGLAFSGAMIYMNIILALNIPD-HWCTVPG----RENTNFS 92
            |...:.|||..||:| .::..:.:.|:.|  |.:::.::...:.|| :||..|.    .|...:|
  Rat     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTF--AFLFVGVVFLGSQPDYYWCRGPRATALAERCAWS 66

  Fly    93 LEEWRDITLPK---QADNRGRKTFSNCEMFQM----NFSEIT-DWSAWNSNLTKTTEACQNGWSY 149
            .||..::|.|:   .|:.||:   .:|..:.:    ..||:: |..|...|.:.....|...|.|
  Rat    67 PEEEWNLTTPELHVPAERRGQ---GHCHRYLLEDTNTSSELSCDPLAAFPNRSAPLVPCSGDWRY 128

  Fly   150 DKTWYESTIPTDHNWVCAKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFC-SLG 213
            .:|  .|||.:..:.||.....:.....:..:..:||:|.||...|.|||..||.||   | .:|
  Rat   129 VET--HSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLIS---CFGVG 188

  Fly   214 RLGSIMC-TSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWSIGTTLMP 277
            ..|.::. ..:::.|:|...:.|:.....:.:..:|..||...:.|..:.......:::|..::|
  Rat   189 ITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILP 253

  Fly   278 LLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKINGHRFDMTE 342
            .:.::...|.......|:|:.:.||:...|.|||||||::::..:|:..|:::||.||
  Rat   254 GIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNG------- 311

  Fly   343 KELAEIYSR----DKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRMAGNPFL 403
            |.|:..||.    |::........|....::.:.|.|:.|:|...||.|..||:....:.||.::
  Rat   312 KHLSSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYM 376

  Fly   404 NFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIYLATFIKF 468
            :|....:||:|..::.....:..|||...:.|.:::.|:||  :.....|....|...:||..:.
  Rat   377 DFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCL--VTAFLPEGIPWLRTTVATLGRL 439

  Fly   469 LNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRAPYYILGVLFLL 533
            ...:.|..|.|...|:|||.:|..||:|.:.|.:..|::||:|::....:.:..|..|.|:|..:
  Rat   440 GITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASV 504

  Fly   534 GGIGALFLPETLHKKLPDTMEEAGHFG 560
            .|...:.||||....||:|:|:....|
  Rat   505 CGGLVMLLPETKGIALPETVEDVEKLG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	133/506 (26%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	97/363 (27%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	139/529 (26%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	97/379 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020