DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_113772.1	Gene:	Slc22a2 / 29503	RGDID:	61936	Length:	593	Species:	Rattus norvegicus

Alignment Length:	589	Identity:	149/589 - (25%)
Similarity:	267/589 - (45%)	Gaps:	68/589 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VDDSEFNDPFQALMEKAGNHGRYQTLYNFVFVGGLAFSGAM--IYMNIILALNIPDHWCTVPG-- 85
            |||         ::|..|....:|....|:..   ..|||.  ||:.|:.....|||.|..||
  Rat     4 VDD---------ILEHIGEFHLFQKQTFFLLA---LLSGAFTPIYVGIVFLGFTPDHHCWSPGAA 56

  Fly    86 --RENTNFSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTKTTE------- 141
              .:...:|..|..:.|:|....:......|.|..::::         ||.:.....:
  Rat    57 KLSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVD---------WNQSTLDCVDPLSSLAA 112

  Fly   142 --------ACQNGWSYDKTWYESTIPTDHNWVCAK----DLF--VTNV-FVVGRVTEVAGSFILG 191
                    .|::||.|:..  .|:|.|:.|.|||.    |||  |.|| |.:       |:.::|
  Rat   113 DRNQLPLGPCEHGWVYNTP--GSSIVTEFNLVCAHSWMLDLFQSVVNVGFFI-------GAMMIG 168

  Fly   192 QMGDSYGRRFVYYISVVFCSLGRLGSIMCTS-SYTWFLIMSGIVGLTVNSLFQSPQIIGMEISRE 255
            .:.|.:||:|...::::..::.  |::|..| :|.|.|:...:.||...:.:....|:..|....
  Rat   169 YLADRFGRKFCLLVTILINAIS--GALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGL 231

  Fly   256 EDRSRIAFFQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRF 320
            ..|..:.......:::|..::..:.:.:.:|....:..::|....||:...:.||||||||:.:.
  Rat   232 GYRRMVGICYQIAFTVGLLILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKI 296

  Fly   321 REAIVQLQKIAKINGHRFDMTEKELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAV 385
            .:|:..::.|||.||....::.:.|.......|: :...|..|....::.::|.|:.::|...:|
  Rat   297 VKAMKIIKHIAKKNGKSVPVSLQNLTPDEDAGKK-LKPSILDLVRTPQIRKHTLILMYNWFTSSV 360

  Fly   386 SYFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYS 450
            .|..|::.......|.:|:|.|.::||.||..:.....|..|||:..:||.:::...||..:...
  Rat   361 LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFIP 425

  Fly   451 TDERYENLMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLG 515
            .|.::  |.|.:|...:....:.:..|.|...|:|||.:|..||.:.:.:.:..|::.|:|||..
  Rat   426 DDLQW--LKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITPFLVYRL 488

  Fly   516 TTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEEAGHF---GKHDKFFSLPKPPQAAEK 577
            |.:.:..|..:..|:.|:.|...|.||||..|.||:|:|:|.:.   .|.::..:|| |.||:..
  Rat   489 TDIWMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDAENMQRPRKKERKENLP-PSQASRP 552

  Fly   578 DDKL 581
            ..||
  Rat   553 SAKL 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	129/516 (25%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	86/358 (24%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	134/538 (25%)
Slc22a2	NP_113772.1	MFS	125..492	CDD:119392	98/380 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020