DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and SLC22A24

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_001129978.2	Gene:	SLC22A24 / 283238	HGNCID:	28542	Length:	552	Species:	Homo sapiens

Alignment Length:	558	Identity:	138/558 - (24%)
Similarity:	230/558 - (41%)	Gaps:	67/558 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNIIL---ALNIPDHWCTVPGRENT------ 89
            |..|:::.|..||:|    ...:.....:..:::.||:|   ....|.|.|.||..:|.
Human     3 FDVLLDQVGGMGRFQ----ICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDND 63

  Fly    90 --NFSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLT------KTTEACQNG 146
              ..|.::...|::|..::.|.:|    |:.|..     ..|...:.|.|      ..||.|.:|
Human    64 TGTLSKDDLLRISIPLDSNLRPQK----CQRFIH-----PQWQLLHLNGTFPNTNEPDTEPCVDG 119

  Fly   147 WSYDKTWYESTIPTDHNWVCAKD---LFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVV 208
            |.||::.:.|||.|:.:.||...   ..|.::|:.|   .:.|..|.|.:.|..||:.:..:
Human   120 WVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAG---SLLGGLIYGHLSDRVGRKIICKL--- 178

  Fly   209 FCSLGRLGSIMCTSSYTWFL---IMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGWS 270
             |.|....|..|.:....||   |:..:.|.:..::..:..|:.:|.:....||.......|.:|
Human   179 -CFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYS 242

  Fly   271 IGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKING 335
            :|..|:..|.:.::.|.......|.|..::.|.|..::||.||||...:..|.:.:|:::|.|||
Human   243 VGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHING 307

  Fly   336 HRFDMTEKELAEIYSR-------DKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLF 393
            .:  .||:.|.....|       |...:...|.|||...:|......:.|....:.|.::.|:|.
Human   308 KK--NTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLILN 370

  Fly   394 SSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRR-----FTNSVSFLISFVTCLPIIVYSTDE 453
            ...:..|..|..:....|...|..|.....:..|||     ||..|...|...|.||       :
Human   371 LQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILVNTFLP-------Q 428

  Fly   454 RYENLMIYLATF-IKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTT 517
            ..:.|.:.|||. |..::|.: .:.::...|:.||.:|.|...:..:.......|||.|:.| ..
Human   429 EMQILRVVLATLGIGSVSAAS-NSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTL-MA 491

  Fly   518 VDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEE 555
            .....|:...||..:|.....|.||||....||:|:::
Human   492 YSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	131/523 (25%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	90/373 (24%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	106/424 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020