DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	149/570 - (26%)
Similarity:	255/570 - (44%)	Gaps:	72/570 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VDDSEFNDPFQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNIILALNIPDHWCTVPG---- 85
            |||         ::|:.|..|.:|. ..|:.:..::.|.|.||:.|:.....|.|:|..||
  Rat     4 VDD---------VLEQVGEFGWFQK-QAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAEL 58

  Fly    86 RENTNFSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEIT-----DWSAWNSNLTK-TTEACQ 144
            .:...:|..|..:.|:|....:......|.|..:::::::.|     ..|:..:|.:: ....|:
  Rat    59 SQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCE 123

  Fly   145 NGWSYDKTWYESTIPTDHNWVCAK----DLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYI 205
            :||.||..  .|:|.|:.|.||..    |||.:.|    .:....||.::|.:.|.:||:....:
  Rat   124 HGWVYDTP--GSSIVTEFNLVCGDAWKVDLFQSCV----NLGFFLGSLVVGYIADRFGRKLCLLV 182

  Fly   206 SVVFCSL-GRLGSIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGW 269
            :.:..|: |.|.::  ...||..|:...:.|:.....:.|...:..|......|...|......:
  Rat   183 TTLVTSVSGVLTAV--APDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAF 245

  Fly   270 SIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKIN 334
            ::|...:..:.:.:..|.......|:||.:.||:..:|.||||||:|::|...|:..:::||:.|
  Rat   246 TVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKN 310

  Fly   335 GHRFDMTEKELA-EIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVLFSSRMA 398
            |.......|.|. |..:.:|:..::  |.||....|.::|.|:.:.|...||.|..|::......
  Rat   311 GKVPPADLKMLCLEEDASEKRSPSF--ADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATG 373

  Fly   399 GNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYENLMIYLA 463
            .|.:|:|.|.|:||.||..:.....|..||.:..:.|.|::...||             |||::.
  Rat   374 ANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACL-------------LMIFIP 425

  Fly   464 TFIKFLNALTFFTVNLQCL-----------------EIYPTCMRQTGVALGTILANAIGVLAPYL 511
            ..:.:||      |.|.||                 |:|||.:|..|:.:.:.|.:..|:..|::
  Rat   426 HELHWLN------VTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFM 484

  Fly   512 VYLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEEAGHFGK 561
            |:....|....|..:.|||.|..|...|.||||....||:|:|||.:.|:
  Rat   485 VFRLMEVWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	135/520 (26%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	96/376 (26%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	140/542 (26%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	110/418 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020