DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_033229.3	Gene:	Slc22a12 / 20521	MGIID:	1195269	Length:	553	Species:	Mus musculus

Alignment Length:	568	Identity:	139/568 - (24%)
Similarity:	231/568 - (40%)	Gaps:	87/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNII--LALNIPDHWCTVPGRENTNFSLEEW 96
            |..|:::.|..||:|.......|..:.:   :...|::  .:..:|.|.|.||..:|:.......
Mouse     3 FPELLDRVGGLGRFQLFQTVALVTPILW---VTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIP 64

  Fly    97 RD--------ITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTKT------TEACQNGW 147
            .|        :::|...|.:..:    |..|:.     ..|....||.|.|      ||.|::||
Mouse    65 GDLGPDVLLAVSIPPGPDQQPHQ----CLRFRQ-----PQWQLTESNATATNWSDAATEPCEDGW 120

  Fly   148 SYDKTWYESTIPTDHNWVC--------AKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYY 204
            .||.:.:.|||.|..:.||        |:.:|:..:.|        |:.:.|...|.:|||.|..
Mouse   121 VYDHSTFRSTIVTTWDLVCNSQALRPMAQSIFLAGILV--------GAAVCGHASDRFGRRRVLT 177

  Fly   205 ISVVFCSL-GRLGSIMCTSSYTW---FLIMSGIVGLTVN--SLFQSPQIIGMEISREEDRSRIAF 263
            .|.:..|: |...:.|.|.....   ||:.|.:.|:.:|  ||.       ||.:..:....:..
Mouse   178 WSYLLVSVSGTAAAFMPTFPLYCLFRFLLASAVAGVMMNTASLL-------MEWTSAQGSPLVMT 235

  Fly   264 FQSCGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQ 328
            ..:.|:|.|..|...:.:.:|.|.......|.|..:..::|.::.||.||||:..:..:.:.:||
Mouse   236 LNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGKLDQGLQELQ 300

  Fly   329 KIAKINGHR-------FDMTEKELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVS 386
            ::|.:|..:       .::....:.|..||||...:.|......|  |...|.|....|.....:
Mouse   301 RVAAVNRRKAEGDTLTMEVLRSAMEEEPSRDKAGASLGTLLHTPG--LRHRTIISMLCWFAFGFT 363

  Fly   387 YFTLVLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYST 451
            ::.|.|....:..|.||......||:.|.......:....|||.. .||||:....|:
Mouse   364 FYGLALDLQALGSNIFLLQALIGIVDFPVKTGSLLLISRLGRRLC-QVSFLVLPGLCI------- 420

  Fly   452 DERYENLMI-------YLATFIKFLNAL--TFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVL 507
               ..|:::       ..|..:..|..|  .|..:.:...|::||.:|.|.|.|..:.|....:|
Mouse   421 ---LSNILVPHGMGVLRSALAVLGLGCLGGAFTCITIFSSELFPTVIRMTAVGLCQVAARGGAML 482

  Fly   508 APYLVYLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEE 555
            .|.:..|| ......|..:.||:.:|.|:.||.||||.:..||||:::
Mouse   483 GPLVRLLG-VYGSWMPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	130/533 (24%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	91/379 (24%)
Slc22a12	NP_033229.3	2A0119	11..526	CDD:273328	135/555 (24%)
Slc22a12	NP_033229.3	MFS	147..516	CDD:119392	94/397 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020