DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7084 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_035526.1	Gene:	Slc22a5 / 20520	MGIID:	1329012	Length:	557	Species:	Mus musculus

Alignment Length:	553	Identity:	153/553 - (27%)
Similarity:	260/553 - (47%)	Gaps:	80/553 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GNHGRYQTLYNFVFVGGL---AFSGAMIYMNIILALNIPDHWCTVPGRENTNFSLEEWRDITLPK 103
            |..|.:|.|..|:....:   .|:|    |:|:.....|:|.|.||...|.:   ..||:.::|.
Mouse    12 GEWGPFQRLIFFLLSASIIPNGFNG----MSIVFLAGTPEHRCLVPHTVNLS---SAWRNHSIPL 69

  Fly   104 QADNRGRKTFSNCEMFQM----NFSEITDWSAWNSNLTK-TTEACQNGWSYDKTWYESTIPTDHN 163
            :..: ||:....|..:::    ||||:......:.:|.: ..|:|.:||.|||..:.|||.|:.:
Mouse    70 ETKD-GRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESCLDGWEYDKDVFLSTIVTEWD 133

  Fly   164 WVCAKDL---FVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVVFCSLGRLGSI----MCT 221
            .||..|.   ..|::|.||   .:.||||.||:.|.:||:     :|:|.::|.....    :.:
Mouse   134 LVCKDDWKAPLTTSLFFVG---VLMGSFISGQLSDRFGRK-----NVLFLTMGMQTGFSFLQVFS 190

  Fly   222 SSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSC-GWSIGTTLMPLLYWWLRH 285
            .::..|.::..:||:...|.:.:..::|.||..:..|...|....| .::.|..::||..:::|.
Mouse   191 VNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRD 255

  Fly   286 WDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKING-------------HR 337
            |...:...::|..:......::.||||||||:.|.:||.|.::|.|||||             ..
Mouse   256 WRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQD 320

  Fly   338 FDMTEKELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMG-FSWCVVAVSYFTLVLFSSRMAGNP 401
            .:.|:.:|..||...:.             |..|..|||. ..|..::|.||.|.|.:..:.|:.
Mouse   321 LNSTKPQLHHIYDLIRT-------------RNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDI 372

  Fly   402 FLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLIS-----FVTCLPIIVYSTDERYENLMIY 461
            ::|....:.||:||||:...:.....||::.|.:..:.     |:..:|           :.:.|
Mouse   373 YVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVP-----------SELFY 426

  Fly   462 LATFI----KFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRA 522
            |:|.:    ||.....:..|.:...|:|||.:|..||.:.:..:....:|:||.|||| ..|...
Mouse   427 LSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLG-AYDRFL 490

  Fly   523 PYYILGVLFLLGGIGALFLPETLHKKLPDTMEE 555
            ||.::|.|.:|..|..||.||:....||||:::
Mouse   491 PYILMGSLTILTAILTLFFPESFGVPLPDTIDQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	144/523 (28%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	103/385 (27%)
Slc22a5	NP_035526.1	2A0119	12..520	CDD:273328	151/548 (28%)
Slc22a5	NP_035526.1	MFS	123..510	CDD:119392	114/419 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020