DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus

Alignment Length:	578	Identity:	151/578 - (26%)
Similarity:	255/578 - (44%)	Gaps:	88/578 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VDDSEFNDPFQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNIILALNIPDHWCTVPG---- 85
            |||         ::|..|..|.:|. ..|:.:..::.|.|.||:.|:.....|||.|..||
Mouse     4 VDD---------VLEHVGEFGWFQK-QAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSPGVAEL 58

  Fly    86 RENTNFSLEEWRDITLPKQADNRGRKTF-SNCEMFQMNFSE--------ITDWSAWNSNLTKTTE 141
            .:...:|..|..:.|:| ...:.|..:| |.|..:::::::        ::..:|..|:|  ...
Mouse    59 SQRCGWSPAEELNYTVP-GLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHL--PLS 120

  Fly   142 ACQNGWSYDKTWYESTIPTDHNWVCAK----DLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFV 202
            .|::||.||..  .|:|.|:.|.||..    |||.:.|    .:....||.::|.:.|.:||:..
Mouse   121 PCEHGWVYDTP--GSSIVTEFNLVCGDAWKVDLFQSCV----NLGFFLGSLVVGYIADRFGRKLC 179

  Fly   203 YYISVVFCSL-GRLGSIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQS 266
            ..::.:..|| |.|.::  ...||..|:...:.|:.....:.|...:..|......|...|....
Mouse   180 LLVTTLVTSLSGVLTAV--APDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQ 242

  Fly   267 CGWSIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIA 331
            ..:::|...:..:.:.:..|.......|:||.:.||:..:|.||||||:|::|..:|:..:::||
Mouse   243 VAFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIA 307

  Fly   332 KINGH------RFDMTEKELAEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTL 390
            :.|..      :....|::.:|..|.       ..|.||....|.::|.|:.:.|...||.|..|
Mouse   308 QKNRKVPPADLKMMCLEEDASERRSP-------SFADLFRTPSLRKHTLILMYLWFSCAVLYQGL 365

  Fly   391 VLFSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERY 455
            ::.......|.:|:|.|.|:||.||..:.....|..||.:..:.|.|::...||
Mouse   366 IMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACL----------- 419

  Fly   456 ENLMIYLATFIKFLNALTFFTVNLQCL-----------------EIYPTCMRQTGVALGTILANA 503
              |||::...:.:||      |.|.||                 |:|||.:|..|:.:.:.|.:.
Mouse   420 --LMIFIPHELHWLN------VTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDL 476

  Fly   504 IGVLAPYLVYLGTTVDIRAPYYILGVLFLLGGIGALFLPETLHKKLPDTMEEAGHFGK 561
            .|:..|::|:....|....|..:.|||.|..|...|.||||....||:|:|||.:.|:
Mouse   477 GGIFTPFMVFRLMEVWQALPLILFGVLGLSAGAVTLLLPETKGVALPETIEEAENLGR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	137/528 (26%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	95/381 (25%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	142/550 (26%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	109/423 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020