DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7084 and Slc22a27

DIOPT Version :9

Sequence 1:	NP_001247235.2	Gene:	CG7084 / 42606	FlyBaseID:	FBgn0038938	Length:	597	Species:	Drosophila melanogaster
Sequence 2:	XP_017173565.1	Gene:	Slc22a27 / 171405	MGIID:	3042283	Length:	576	Species:	Mus musculus

Alignment Length:	562	Identity:	135/562 - (24%)
Similarity:	245/562 - (43%)	Gaps:	58/562 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FQALMEKAGNHGRYQTLYNFVFVGGLAFSGAMIYMNIIL---ALNIPDHWCTVPGRENTN----- 90
            ||.|:.:.|:.||:|.| ..||   |....|::..:|.:   ...||:|.|.||..:|..
Mouse    28 FQELLNQVGSLGRFQIL-QIVF---LLLLNAIVVPHIAMENFTAAIPNHRCWVPILDNDTASDNG 88

  Fly    91 ---FSLEEWRDITLPKQADNRGRKTFSNCEMFQMNFSEITDWSAWNSNLTK-TTEACQNGWSYDK 151
               .|.::...|::|..::.|..|    |..|......:...:...||::: .||.|.:||.||:
Mouse    89 SRILSQDDLLRISIPLDSNLRPEK----CRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDR 149

  Fly   152 TWYESTIPTDHNWVC--------AKDLFVTNVFVVGRVTEVAGSFILGQMGDSYGRRFVYYISVV 208
            :.:.|||.|:.:.||        .|..|:..:|:        |..|.|.:.|..||:|     ::
Mouse   150 SNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFI--------GGIICGHLSDRLGRKF-----IL 201

  Fly   209 FCSLGRLG----SIMCTSSYTWFLIMSGIVGLTVNSLFQSPQIIGMEISREEDRSRIAFFQSCGW 269
            .|:|.:..    .:....|:..:..:..:.||:|..:..:..::.:|.:..:..:.:|...||..
Mouse   202 TCALLQFAITETCVAFAPSFFIYCSLRFLAGLSVEPILVNSHLLMLEWTSPKFLTMMAALLSCAP 266

  Fly   270 SIGTTLMPLLYWWLRHWDSFMWLTSIPTAMVLLFSKYVIESPRWLISKQRFREAIVQLQKIAKIN 334
            :||..:...|.:..|.|.......|:|....|:.::::.||.||||...:.::.:.:|:|:|.:|
Mouse   267 NIGYMISAGLAFLFRIWHHLQLTMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMN 331

  Fly   335 G--HRFDMTEKEL-----AEIYSRDKQDVTYGIASLFAGWRLARNTTIMGFSWCVVAVSYFTLVL 392
            |  :..|:|.:.:     ||:.:...:.   .:..||....|.:...::.|......||.|.|.:
Mouse   332 GMKNSGDLTMEIVRTSMKAELEAAKTKP---SLRDLFHTSILRKRICVLSFMRLFFTVSIFGLAV 393

  Fly   393 FSSRMAGNPFLNFLYQSIVEIPAYVVGRYMGDTYGRRFTNSVSFLISFVTCLPIIVYSTDERYEN 457
            ....::.|..|.....|.:.|...|:|.::.:..|||.|..|  |:|......:|.....:..:.
Mouse   394 HLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLV--LMSLRGIFILIAVFVPQEMQT 456

  Fly   458 LMIYLATFIKFLNALTFFTVNLQCLEIYPTCMRQTGVALGTILANAIGVLAPYLVYLGTTVDIRA 522
            |.|.:||..:.:::|......|...|:.||.:|.|.|.:.....|:...|:|..:.|.|.. ...
Mouse   457 LRIIMATLAEGISSLCVGVSRLHTNELLPTTLRATAVGVIGFFGNSGSFLSPLFMLLATYY-ANM 520

  Fly   523 PYYILGVLFLLGGIGALFLPETLHKKLPDTMEEAGHFGKHDK 564
            |:...|...:........||||.::.|||:..:.|:..|..:
Mouse   521 PWIFYGGFSIFNAFTVFLLPETKNQPLPDSTHDVGNDWKESR 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7084	NP_001247235.2	2A0119	64..552	CDD:273328	121/518 (23%)
CG7084	NP_001247235.2	MFS	184..542	CDD:119392	81/368 (22%)
Slc22a27	XP_017173565.1	MFS_OAT	134..540	CDD:340932	97/424 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010