Protein Alignment Gld2 and wisp

DIOPT Version :10

• Sequence 1: NP_651012.2
• Gene: Gld2 / 42602
• FlyBaseID: FBgn0038934
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: NP_572766.1
• Gene: wisp / 32152
• FlyBaseID: FBgn0260780
• Length: 1373
• Species: Drosophila melanogaster
• Alignment Length: 1541
• Identity: 399/1541 - (25%)
• Similarity: 615/1541 - (39%)
• Gaps: 423/1541 - (27%)

  Fly     8 AAAASSSAAAATATTTAISNSTN--------TTASPATTN--------TINTTTKTITTSEVPLE 56
            ||..:.|:..||..|:.....:.        :..||::.:        ..|..|..: ..:|...
  Fly    14 AADVAESSVTATCNTSVQQQQSQQLEFRTRMSAGSPSSKSGQCHLKFGKYNNKTANL-LRQVNSC 77

  Fly    57 PASNMAPKALEIEDSGRNEPEDLEHGAAKPLEQRKTTVVHTCPRPPGGYKYSMEFLYGIGSGMAG 121
            .:||.:      .::..|..|.::....:||....:...|:..|.    ||     :|.|:....
  Fly    78 HSSNSS------SNTSNNNNEAIKGQQQQPLHYCNSNNSHSWARK----KY-----FGNGNSNNS 127

  Fly   122 IPLNIPTPSSITPR-------TVRSTAPLLTTHMPLLTNMGVAPSRPSGIRYPGSAGGSNGTTVA 179
            :......|||...|       .::........:..|:.|..|..:..|..:   |:..:|.:|
  Fly   128 LLQQQQQPSSFFQRQQQQHQMQMQQEKQATNNNDALMKNQNVVNAHVSDCK---SSDSNNNST-- 187

  Fly   180 ASTTPSTTVTTSSGSPGSGAEAITSSVSSSGLPAAGLQAAQFICQGYMPTGPQRRLWHAENAVWQ 244
            :|:..::|:::::.:..|.:...|.|.||              |..  .|.|.:  |..||:...
  Fly   188 SSSNNNSTISSNNNNTSSASNNNTGSSSS--------------CSN--RTKPAK--WLNENSSSS 234

  Fly   245 FDRN-----YPYNQAYSPPYGIPMMPVGFEHPYGQRIIYPGYY--NQTPPGINPAAVAG----LT 298
            ...|     ...|...|         :..:...........||  :::..|.:..|...    .|
  Fly   235 SSSNNNNISCRNNNTSS---------IDTKRRNSSAGATAAYYRKSESESGSSEGAAESTETEAT 290

  Fly   299 RT-----NRPV-TQQPHILTQPAVGTTESSEEAPATLGNAP--QVSSTWRYGRPGTHRGRHAVPT 355
            ||     ||.. :......||..:|.::..|: ..|:...|  |..|.|:...|.|
  Fly   291 RTGGCNSNRTAESSSADGGTQATMGKSQDQEQ-DQTVKQRPRQQPLSFWKTNYPQT--------- 345

  Fly   356 AAAPALLHRDSKSFYNSIGSGMANGPRFKAPFVANVRNFQAGAVATVAAGGAATTAVVGTSAPAT 420
             :|..|..::                                   ||||  ..:.|.|..:|.|.
  Fly   346 -SATQLKDKE-----------------------------------TVAA--VVSAAAVAAAAAAA 372

  Fly   421 GAASSSDQNVATKRNHQGAATQNNHRNRHN--------------------------AKKGGKNSV 459
            .|:....|..:....|:..:....|: :||                          .:|...|:.
  Fly   373 SASEQQQQQQSLSIEHRRNSGYQQHQ-QHNYYPYYYSQPKQLTIASFLQKEMLPDSTEKSSSNTG 436

  Fly   460 GKELTSNSSESLSNSSSKSQLNKRPSSSSSISPIKHPHRN-------YRNRMRYTATEPT----E 513
            |..:..:||...|| .|:.|...: |:.|.....:..:||       |:::.::.|.:.|    .
  Fly   437 GSNMIRSSSNGNSN-FSRHQYGHQ-STGSGYQQQQQRYRNAQNVYQQYQHQQQHHAQQHTHPHFR 499

  Fly   514 QKAATTTVPIS---NYQPP----------------------QQSTSTVRRTSKFQGSNAYQAHTA 553
            :|.:.....|:   :|.||                      ||.|..:..:|.|   ||......
  Fly   500 RKHSDNGSGINKKMHYSPPGKSGDPADRSASGQQQHHHPHQQQKTIEILASSHF---NAMHRRMQ 561

  Fly   554 AGRQQSRFYQSRH--MDGYV----FQSGHYMVY-----------------AAGAPPVGLRP---G 592
            .|..::.:||..:  |.|.|    .:|.|..:|                 |||:.|| ::|   .
  Fly   562 GGNNKNGYYQHSYNPMTGEVGSTPTRSEHQNIYNLTYIHVDTEATGEAASAAGSTPV-VKPSLLS 625

  Fly   593 KSPVSEATGAPPGAAAATAAAATAVAATAAAAEGGG-----------------AAEGGGAAAAPV 640
            |..:|....:.........|...||.:.:|.|.|..                 |..||....:||
  Fly   626 KPNISITPASSTTPTTVDRALLPAVRSVSAPASGSALPAPANHVRNMFPPPPLAMLGGHGLLSPV 690

  Fly   641 TA----------------SSATLEGEQPLDSDF----------DQRQEFADLGLDPANGGFSSDL 679
            |.                ::|...|::...|..          .|:|:...|...|...|.||..
  Fly   691 TTTTPTKMISCAQLDEAITAAAASGDKLSTSPSYNQAGHYIMPPQQQQQQQLSSHPIPTGTSSHP 755

  Fly   680 EP------------------NGIKQDTSELDTHSCLISHP--------------NSEVDGDDNQ- 711
            .|                  .|.:...:.:..||....:|              .|..:.|.|.
  Fly   756 PPPPPPHMFFHFADGFCNPGQGHQAPPATMWPHSSSPCYPASYGSSCGSGTGAGTSPHNNDGNAG 820

  Fly   712 SLASFAPSVESDDSDSELSDASVESVAR-----DILVSCLAVATGAEEPDFSGPNLVPYGDMHYL 771
            :|...:|::.|....||...:...:.:|     ...:|....|.|:.:   ..|:|   .:|...
  Fly   821 ALRPASPALSSSSLGSESQWSGTSNRSRLGHNGHPSISPTPSALGSAQ---LSPHL---AEMRVQ 879

  Fly   772 KELDKKNPPTNGYRSHRPYHQSHYAYHSQMSPRGLSCCGDMLNQHSEDLVFKLDQNQPDGIESGK 836
            ..|.:::||:  :.||||        |.||....:|.
  Fly   880 HPLHQQHPPS--HASHRP--------HGQMGGHAMSS---------------------------- 906

  Fly   837 NIFLREITEQPDNISVASNLSCSPSASSSKSVLAPMASKSNITMPEENNDDDELPLVVHNRYWRE 901
              ::......|.:.|::     ||:.:       |:|:.:                   ...|.|
  Fly   907 --YVPHRPPPPPHPSIS-----SPNPT-------PVATGA-------------------GGPWYE 938

  Fly   902 FFGYTPADRFLLRAKFVEMRRPPKVMGCKNKWDPLSLSVWKKFLESQQTRHVYKIKMRLWRAIYT 966
            ..  .|.||:|.:|:.:|:...|:.:.|..|:|.||..:||:|..:|||.:.:|:||||||.:|.
  Fly   939 MI--LPPDRYLAQARNIEVTVQPEKLICMCKYDNLSAEIWKRFRGAQQTHNKFKLKMRLWRYLYL 1001

  Fly   967 -VAMKNYPRYGLYLVGSSISYFGSKCSDMDICML--ACTNP-----------NIDSRMEAVYHLH 1017
             :....:.||.:.||||:|:.||:..||:|:|:|  ...:|           :.:.|.||:..|.
  Fly  1002 WMHQPMFERYRICLVGSTITGFGTDSSDIDMCLLPEQGVHPHQHQYHQHHHFHNEKRTEALIILT 1066

  Fly  1018 VMKELLGRTNMFQDFNLIEARVPILRFTDRCHKVEVDINFNNSVGIRNTHLLYCYSQLDWRVRPM 1082
            :...:|..|.:||||||||||||||||.|..:.:|||:||||.|||:||:||..|:|:|||.||:
  Fly  1067 LFNAVLKDTEVFQDFNLIEARVPILRFKDISNGIEVDLNFNNCVGIKNTYLLQLYAQMDWRTRPL 1131

  Fly  1083 ALTVKQWAQYHNINNAKNMTISSYSLMLMVIHFLQVGASPPVLPCLHNLYPEKFGLLQPNDFGYV 1147
            .:.||.|||||:||:||.||||||||:|||:|:||....|.||||||:||||||.|.| .|...:
  Fly  1132 VVIVKLWAQYHDINDAKRMTISSYSLVLMVLHYLQHACVPHVLPCLHSLYPEKFQLGQ-QDCLDL 1195

  Fly  1148 DMNEVMAPYQSDNSQTLGDLLLSFLHYYSVFDYGKYAISIRVGGVLPIEVCRAATAPKNDIHQWN 1212
            |:.|.:.|||:.|:||||:.||.|..|||.||:..:|||||.|||||:..||.|.:||||::||.
  Fly  1196 DLIEPIEPYQALNTQTLGEHLLGFFKYYSTFDFRNFAISIRTGGVLPVSTCRMAKSPKNDVYQWK 1260

  Fly  1213 ELCIEEPFDQTNTARSVYDTDTFERIKTIFVASYRRLDSTRNLSAIF-------EDYDGPTILMQ 1270
            ||.||||||.:||||||||..||||:|.:|:.|.||||.|.:|:.||       |.:  |.:...
  Fly  1261 ELNIEEPFDLSNTARSVYDGPTFERVKAVFLISARRLDHTLDLATIFRPIHHVPEHF--PQLQQH 1323

  Fly  1271 QPSVDSEIELYEGQHHRLLPNRGSSRSNSAIPSPRPSILMVDKATT 1316
            |...:.::      ||.:...:.|:.......:|.||.|..|.|:|
  Fly  1324 QQQFEQQL------HHPISGQQRSAGGGGDGANPVPSTLNPDAAST 1363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gld2	NP_651012.2	TRF4	<977..>1277	CDD:227585	169/319 (53%)
wisp	NP_572766.1	TRF4	<1017..>1290	CDD:227585	154/273 (56%)