Protein Alignment Gld2 and TUT4

DIOPT Version :10

• Sequence 1: NP_651012.2
• Gene: Gld2 / 42602
• FlyBaseID: FBgn0038934
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: XP_005270733.1
• Gene: TUT4 / 23318
• HGNCID: 28981
• Length: 1652
• Species: Homo sapiens
• Alignment Length: 665
• Identity: 152/665 - (22%)
• Similarity: 260/665 - (39%)
• Gaps: 218/665 - (32%)

  Fly   637 AAPVTASSATLEGEQPLDSDFDQRQEFADLGLDPANGGFSSDLEPNGIKQDTSELDTHSC-LISH 700
            |.|.|      :|......||.:|::           |..|:.:|  :|  ::.:.|:.| |:..
Human   708 ACPQT------KGGNKSTVDFKKREK-----------GKISNKKP--VK--SNNMATNGCILLGE 751

  Fly   701 PNSEVDGDDNQSLASFAPSVESDDSDSELSDASVESVARDILVSCLAVATGAEEPDFSGPNLVPY 765
            ...:::.:..|       .|:.|:.|.......:::  .::||:
Human   752 TTEKINAEREQ-------PVQCDEMDCTSQRCIIDN--NNLLVN--------------------- 786

  Fly   766 GDMHYLKELDKKNPPTNGYRSHRPYHQSHYAYHSQMSPRGLSCCGDMLNQHSEDLVFKLDQNQPD 830
                   |||                   :|.|.|.|       ..:....|.::..|||:.| |
Human   787 -------ELD-------------------FADHGQDS-------SSLSTSKSSEIEPKLDKKQ-D 817

  Fly   831 GIESGKNIFLREITE----------QPDNISVASNLSCSPSASSSKSVLAPMASKS-NITMPEEN 884
            .:...:....:|:::          .||..:.....|...:.||.:||....::.| |....|:.
Human   818 DLAPSETCLKKELSQCNCIDLSKSPDPDKSTGTDCRSNLETESSHQSVCTDTSATSCNCKATEDA 882

  Fly   885 ---NDDDELPLVVHNRYWREFFGYTPADRFLLRAKFVEMRRPPKV-------------------- 926
               ||||.||.       :|.  |...|:|:|.:     .:||.:
Human   883 SDLNDDDNLPT-------QEL--YYVFDKFILTS-----GKPPTIVCSICKKDGHSKNDCPEDFR 933

  Fly   927 -------------------MGCKNKWDPLS------------LSVWKKFLESQQTRHVYKIKMRL 960
                               :.||..:|.||            |...:||::.:     |..|.|
Human   934 KIDLKPLPPMTNRFREILDLVCKRCFDELSPPCSEQHNREQILIGLEKFIQKE-----YDEKAR- 992

  Fly   961 WRAIYTVAMKNYPRYGLYLVGSSISYFGSKCSDMDICMLACTNPNID--SRMEAVYHL-HVMKEL 1022
                            |.|.|||.:.||.:.||:||||....:.|.:  :..|.:.:| .::|..
Human   993 ----------------LCLFGSSKNGFGFRDSDLDICMTLEGHENAEKLNCKEIIENLAKILKRH 1041

  Fly  1023 LGRTNMFQDFNLIEARVPILRFTDRCHKVEVDINFNNSVGIRNTHLLYCYSQLDWRVRPMALTVK 1087
            .|..|:..   :..|:|||::|..|...:|.||:..|::...||.:|..|:.:|.||:.:..|:|
Human  1042 PGLRNILP---ITTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMK 1103

  Fly  1088 QWAQYHNINNAKNMTISSYSLMLMVIHFLQVGASPPVLPCLHNLY-----PEKFGLLQPNDFGYV 1147
            .:|:..:|.:|...::|||:.:|||::||| ...|||:|.|..::     |::  ::...:..:.
Human  1104 VFAKRCDIGDASRGSLSSYAYILMVLYFLQ-QRKPPVIPVLQEIFDGKQIPQR--MVDGWNAFFF 1165

  Fly  1148 DMNEVM---APYQSDNSQTLGDLLLSFLHYYS-VFDYGKYAISIRVGGVLPIEVCRAATAPKNDI 1208
            |..|.:   .|....|:::||:|.|..|.:|: .||:.:|.||||...:|       .|..|
Human  1166 DKTEELKKRLPSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIRQKKLL-------TTFEK--- 1220

  Fly  1209 HQWNELC--IEEPFD 1221
             ||...|  ||:|||
Human  1221 -QWTSKCIAIEDPFD 1234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gld2	NP_651012.2	TRF4	<977..>1277	CDD:227585	84/259 (32%)
TUT4	XP_005270733.1	rplD	97..>199	CDD:184900
		TUTase	254..471	CDD:465974
		PAP_assoc	628..677	CDD:427532
		TRF4	929..>1261	CDD:227585	95/345 (28%)
		NT_PAP_TUTase	971..1089	CDD:143392	38/142 (27%)
		PTZ00368	<1280..1375	CDD:173561
		Atrophin-1	1404..>1593	CDD:460830