Protein Alignment Gld2 and Tut7

DIOPT Version :10

• Sequence 1: NP_651012.2
• Gene: Gld2 / 42602
• FlyBaseID: FBgn0038934
• Length: 1364
• Species: Drosophila melanogaster
• Sequence 2: NP_001360893.1
• Gene: Tut7 / 214290
• MGIID: 2387179
• Length: 1534
• Species: Mus musculus
• Alignment Length: 882
• Identity: 203/882 - (23%)
• Similarity: 330/882 - (37%)
• Gaps: 198/882 - (22%)

  Fly   444 NHRNRHNAKKGGKNSVGKELTSNSSESLSNSSSKSQLNKRPSSSSSISP----IKHP-----HRN 499
            |.....:.|...|:||..|.|.||:.  ..||:|.:..|..::.....|    |||.     .:.
Mouse   492 NKLGNFSLKDVEKDSVVWEYTDNSTG--DTSSAKEEAPKETAAKKGQVPLTFNIKHQPSVPVGQL 554

  Fly   500 YRNRMRYTATE-----------------------PTEQKAATTTVPISNYQPPQQSTSTVRRTSK 541
            :...:|:.|.|                       |.::.|         .:.|......|.||..
Mouse   555 WVELLRFYALEFNLADLVISIRVKELISRESKDWPKKRIA---------IEDPYSVKRNVARTLN 610

  Fly   542 FQGSNAYQAHTAAGRQQSRFYQSRHMDGYVFQSGHYMVYAAGAPPVGLRPGKSPVSEATGAPPGA 606
            .|....|..|..  |...:::...|.   |.:..      ...||..:.....|..||....|..
Mouse   611 NQPVFEYILHCL--RTTYKYFALPHK---VTKPN------LTKPPSPVTCVSDPYREAKNGGPEP 664

  Fly   607 AAATAAAATAVAATAAAAEGGGAAEGGGAAAAPVTASSATLEGEQPLDS-----DFDQRQEFADL 666
            .|.....    ...||.|:..|....|...|..||..:.|.|...|...     .....||
Mouse   665 QATNIDK----LGNAAVAQDPGVQTSGDCRAQLVTLKNTTEEVGSPAKEKTGGVHIPAHQE---- 721

  Fly   667 GLDPANGGFSSDLEPNGIKQDTSEL-DTHSCLISHPNSEVD-------GDDNQSLASFA-PSVES 722
                ::|...:::...|::..|:|| :|.|     .|.||.       ..|:|.|:|.. |.:::
Mouse   722 ----SSGCVQAEVSCEGLEDATAELPETGS-----DNEEVRRKTKHPLSTDDQGLSSSKHPELQN 777

  Fly   723 DDSDSEL-SDASVESVARDILVSCLAVATGAE--EPDFSGPNLVPYGDMHYLKELDKKNPPTNGY 784
            ..|...| :|.::|.||.: ..||.::...||  |....|..     ::.....|...:|.....
Mouse   778 CGSLCGLQADNTLELVAEE-CNSCASLDNKAEVNEERIEGAE-----ELEEAAALSCFSPSVQSR 836

  Fly   785 RS---HRPYHQSHYAYHSQMSPR-GLSCCGD---MLNQHSEDLVFKLDQNQPDGIESGKNIFLRE 842
            .|   |....:.......:..|| .::...|   :.|:|..|..:         ..||:...|.|
Mouse   837 TSAAMHFDDEEEEEEEEEEEEPRLSINLTEDEEGVANEHQVDSRY---------AGSGEEDALSE 892

  Fly   843 ITEQPDNISVASNLSCSPSASSSKSVLAPMASKSNITMPEENNDDDELPLVVHNRYWREFFGYT- 906
            ..:..:.........|..:...:.     :...:.||:.||:..:::|| ...:.::.||...|
Mouse   893 EDDLAEPAKGEDTGECGENVGGTL-----LIDLNRITLKEESFPEEDLP-GDQSEFFYEFRKLTF 951

  Fly   907 -----------------------PADRFLLRAKFVEMR-RPPKVMGCKNKWDPLSLSVWKKF--- 944
                                   |.|     .|.|::. .||......|..|.:.:..:|.|
Mouse   952 TKGKSPTVVCSLCKREGHLKKDCPED-----FKRVQLEPLPPLTPKFSNILDQVCVQCYKDFSPT 1011

  Fly   945 -LESQQTRHVYKIKMRLWRAIYTVAMKNYPRYGLYLVGSSISYFGSKCSDMDICMLACTNPNIDS 1008
             :|.|...|:.       :.:.:...:::|...|.|.|||.:.||.|.||:|:||..    |...
Mouse  1012 IVEDQAREHIR-------QNLESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTI----NGHE 1065

  Fly  1009 RMEAVYHLHVMKELL-------GRTNMFQDFNLIEARVPILRFTDRCHKVEVDINFNNSVGIRNT 1066
            ..|.:..:..::||.       |..|:..   :..|:|||::|......:||||:..|::.:.||
Mouse  1066 TAEGLDCVRTIEELARVLRKHSGLRNILP---ITTAKVPIVKFFHLRSGLEVDISLYNTLALHNT 1127

  Fly  1067 HLLYCYSQLDWRVRPMALTVKQWAQYHNINNAKNMTISSYSLMLMVIHFLQVGASPPVLPCLHNL 1131
            .||..||.:|.||:.:..|:|.:.:..:|.:|...::|||:..|||::||| ..||||:|.|..:
Mouse  1128 RLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQ-QRSPPVIPVLQEI 1191

  Fly  1132 YPEKFGLLQP-------NDFGYVDMNEVMA--PYQSDNSQTLGDLLLSFLHYYS-VFDYGKYAIS 1186
            |.   |..:|       |.:.:..:||:..  |....|::.:|.|.|..|.:|: .||:.::.||
Mouse  1192 YK---GEKKPEILVDGWNIYFFDQINELPTCWPEYGKNTEPVGQLWLGLLRFYTEEFDFKEHVIS 1253

  Fly  1187 IRVGGVLPIEVCRAATAPKNDIHQWNE--LCIEEPFD 1221
            ||...:|       .|..|    ||..  :.||:|||
Mouse  1254 IRRKSLL-------TTFKK----QWTSKYIVIEDPFD 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gld2	NP_651012.2	TRF4	<977..>1277	CDD:227585	86/264 (33%)
Tut7	NP_001360893.1	TUTase	194..411	CDD:465974
		PAP_assoc	550..599	CDD:427532	5/57 (9%)
		2A1904	<673..>910	CDD:273344	55/264 (21%)
		TRF4	975..>1306	CDD:227585	100/339 (29%)
		ZnF_C2HC	1342..1357	CDD:197667
		TUTF7_u4	1365..1446	CDD:465208
		ZnF_C2HC	1448..1464	CDD:197667