DRSC/TRiP Functional Genomics Resources

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Protein Alignment SKIP and Sash3

DIOPT Version :9

Sequence 1:NP_001262827.1 Gene:SKIP / 42601 FlyBaseID:FBgn0051163 Length:1080 Species:Drosophila melanogaster
Sequence 2:NP_001300678.1 Gene:Sash3 / 74131 MGIID:1921381 Length:381 Species:Mus musculus


Alignment Length:372 Identity:115/372 - (30%)
Similarity:163/372 - (43%) Gaps:61/372 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   509 ESPSLSPSPSSDYEDIGVTR--------------------GHGCLPPSLLAAKAKKNGLPHGKAN 553
            :...||...||.::|...::                    ..|.|.|.......||.|   .|..
Mouse    16 QKKKLSLQRSSSFKDFAKSKPSSPVVSEKEFNLDDNIPEDDSGVLTPEDSGKSGKKLG---KKWR 77

  Fly   554 TICQKATVHHSGEM--RSSAKEIGAFNENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFACSAS 616
            .:..:......|:|  ::.::|:|...|.|    :...||.|.|     .|.......|.|.:..
Mouse    78 AVISRTMNRKMGKMMVKALSEEMGDTLEEG----SASPTSPDCS-----LDSPGPEKMALAFTEQ 133

  Fly   617 SVESLPSAS--GSSTQALVRPGSPHSSISAED-RTSMASCIC-KAKALVDSLPNPYDKEALKFKK 677
            .....||.|  .|:...|..||....|...|. ........| :|:...|..|:|||.::||.:|
Mouse   134 EEREPPSLSRQTSTGSELCSPGPGSGSFLEESPAPQYTGPFCGRARVHTDFTPSPYDHDSLKLQK 198

  Fly   678 GDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAG----SRLANSGNGSH 738
            ||:|.::.....|.|.|..:|::|.||||.|:||||:          |.|    ||..:.|.   
Mouse   199 GDVIQIVEKPPVGTWLGLLNGKLGSFKFIYVDVLPEE----------AVGPVRPSRRQSKGK--- 250

  Fly   739 NGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHD 803
            ...|.::.:||.||||:|:||..:||||:.||.||||....|:.|.|::.:||||||||.:||  
Mouse   251 RPKPKTLHELLERIGLEEHTSTLLLNGYQTLEDFKELRETHLNELNIMDPQHRAKLLTAAELL-- 313

  Fly   804 IECSDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGS 850
               .|.|..||....:.|..:...:.|..|. .:...||||||:|||
Mouse   314 ---LDYDTAGSEEAEEGAESSQEPVAHTVSE-PKVDIPRDSGCFEGS 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SKIPNP_001262827.1 SAM_Samd5 4..65 CDD:188926
SAM 7..65 CDD:197735
SH3 657..710 CDD:302595 22/52 (42%)
SAM 738..801 CDD:197735 31/62 (50%)
SAM_superfamily 742..800 CDD:301707 31/57 (54%)
Sash3NP_001300678.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76 11/62 (18%)
SLY 21..174 CDD:315207 33/164 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..168 20/80 (25%)
SH3_SASH3 176..231 CDD:212901 22/54 (41%)
SAM_superfamily 250..317 CDD:326639 34/74 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11383
eggNOG 1 0.900 - - E1_KOG4384
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8772
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR12301
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5033
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
76.900

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