DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SKIP and Samsn1

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_075869.2	Gene:	Samsn1 / 67742	MGIID:	1914992	Length:	372	Species:	Mus musculus

Alignment Length:	417	Identity:	110/417 - (26%)
Similarity:	179/417 - (42%)	Gaps:	97/417 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 RFSTVSIGTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTRGHGCLPPSLLA---AKAKKNG 546
            |.::||...::.....|.|:.|..|....|.|             .|.|...:.|   ...||.|
Mouse    31 RNNSVSKSDDSIEVHDRELTNGSEEQSKTSSS-------------GGSLGKKVRAISWTMKKKVG 82

  Fly   547 LPHGKANTICQKATVHHSGE----MRSSAKEIGAFNENGRNFVATKDTSRDFSNSQDNTDRGSMS 607
            ..:.||   ..:.....|||    .|:|...||..         |:..|...|:|.|:...|..|
Mouse    83 KKYIKA---LSEEKEEESGEEALPYRNSDPMIGTH---------TEKISLKASDSMDSLYSGQSS 135

  Fly   608 DQAF-ACSASSVESLPSASGSSTQALVRPGSPHSSISAEDRTSMASCIC-KAKALVDSLPNPYDK 670
            .... :||          .|:|.:         .|...:|.:..:...| :||...|..|:|||.
Mouse   136 SSGITSCS----------DGTSNR---------DSFRLDDDSPYSGPFCGRAKVHTDFTPSPYDT 181

  Fly   671 EALKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGN 735
            ::||.||||:||::.....|:|.|..:.:||:||||.|:|:.|:.......|...:..|
Mouse   182 DSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVILEEEAAPKKIKVPRSRRR------ 240

  Fly   736 GSHNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQL 800
            .:|.    ::::.|.||.|:||||..:|||||.|:..|:::.:.|..|.|.:.|.||:||:|.:.
Mouse   241 ENHQ----TIQEFLERIHLQEYTSTLLLNGYETLDDLKDIKESHLIELNIADPEDRARLLSAAES 301

  Fly   801 LHD----IECSDVDIPGSSSEN--DEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPT 859
            |.|    :|.....:|.||:.:  ..::|.:.              |||||||
Mouse   302 LLDEETTVEHEKESVPLSSNPDILSASQLEDC--------------PRDSGCY------------ 340

  Fly   860 QAVNSTDESNSLDDVVTKCSSEIMKRV 886
              ::|.:..|..:|:.::..|::::::
Mouse   341 --ISSENSDNGKEDLESENLSDMVQKI 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	25/52 (48%)
		SAM	738..801	CDD:197735	25/62 (40%)
		SAM_superfamily	742..800	CDD:301707	24/57 (42%)
Samsn1	NP_075869.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		11/52 (21%)
		SLY	17..164	CDD:289268	37/176 (21%)
		Important for interaction with 14-3-3 proteins	20..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..111		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..153		7/42 (17%)
		SH3	167..218	CDD:302595	23/50 (46%)
		SAM_SAMSN1	239..304	CDD:188960	27/74 (36%)
		SAM	245..304	CDD:197735	25/58 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..372		17/90 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11383
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8772
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12301
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5033
SonicParanoid	1	1.000	-	-		X5009
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.900