DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SKIP and CASKIN2

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_065804.2	Gene:	CASKIN2 / 57513	HGNCID:	18200	Length:	1202	Species:	Homo sapiens

Alignment Length:	667	Identity:	134/667 - (20%)
Similarity:	190/667 - (28%)	Gaps:	284/667 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 IGVTRGHGCLPPSLLAAKAKKNGLPHGKANTICQKATVHHSGEMRSSAKEIGAFNENGRNFVATK 588
            :....||..:...||.|..:.|  ...|..|...:|.::...|:.....| |..:.|.||  ...
Human   195 LAAKNGHREVIRQLLRAGIEIN--RQTKTGTALHEAALYGKTEVVRLLLE-GGVDVNIRN--TYN 254

  Fly   589 DTSRDFSNSQDNTDRGSMSDQAFACSASSVESLPSASGSSTQALVRPGSPHSSISAEDRTSMASC 653
            .|:.|..|.             |..|.:|.|         .:.|:|.               ||.
Human   255 QTALDIVNQ-------------FTTSQASRE---------IKQLLRE---------------ASG 282

  Fly   654 ICKAKALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGRCH------GRVGHFKFINVEV-- 710
            |.|.:||.| ..|.:|..||..:.||:|.||..:..|.|||..|      .|:|:|....|||
Human   283 ILKVRALKD-FWNLHDPTALNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVS 346

  Fly   711 ----LPEQRM--------------------------------------------------KNSSS 721
                :|..|:                                                  :.|..
Human   347 KRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPLTYSQLPRVGLSPDSPAGDRNSVGSEGSVG 411

  Fly   722 KTLAAGSRLANSGNGSHNGG---------PCSVEDLLI--------------------RIG---- 753
            ...:|||..::.|...|..|         |.:.||.::                    |.|
Human   412 SIRSAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIF 476

  Fly   754 --------------------------LKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRA 792
                                      |:.||:.|:..|| |:.....:.|.||..:|:....||.
Human   477 TQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGY-DVPTISRMTPEDLTAIGVTKPGHRK 540

  Fly   793 KLLTAVQLLHDIECSDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQT 857
            |:.:.:..|...|.....||....|                          ..|..|.|    |.
Human   541 KIASEIAQLSIAEWLPSYIPTDLLE--------------------------WLCALGLP----QY 575

  Fly   858 PTQAVNSTDESNSLDDVVTKCSSEIMKRVESARRCKDNPFKTTLPGGGRLG--KKSFLG------ 914
            ..|.|:|..:|..|   |...:.|.::.:                |..:||  ||..||
Human   576 HKQLVSSGYDSMGL---VADLTWEELQEI----------------GVNKLGHQKKLMLGVKRLAE 621

  Fly   915 -GNGLMADDTLTRGGLSEKSSDSGVSSSSLSSGPLKSSTXHLPTILAHELLLGVGSGMGMGLGLG 978
             ..||:..:.|:.||            ..|:.|         |.::|.|   |:.:|.|
Human   622 LRRGLLQGEALSEGG------------RRLAKG---------PELMAIE---GLENGEG------ 656

  Fly   979 TMSHGTTG--TLTPHGVATATSPTAHSAPLGNICNTLPHAPSSS--------------------- 1020
               ..|.|  .||..|  :..||...:|..|.....||..|:.|
Human   657 ---PATAGPRLLTFQG--SELSPELQAAMAGGGPEPLPLPPARSPSQESIGARSRGSGHSQEQPA 716

  Fly  1021 ---GGGGVSSSMASNLP 1034
               .||..|.....|||
Human   717 PQPSGGDPSPPQERNLP 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	21/58 (36%)
		SAM	738..801	CDD:197735	21/121 (17%)
		SAM_superfamily	742..800	CDD:301707	19/107 (18%)
CASKIN2	NP_065804.2	ANK	7..135	CDD:238125
		ANK repeat	7..46	CDD:293786
		ANK repeat	48..79	CDD:293786
		ANK 1	48..77
		Ank_2	53..145	CDD:289560
		ANK	76..209	CDD:238125	2/13 (15%)
		ANK 2	81..110
		ANK repeat	85..112	CDD:293786
		ANK repeat	114..145	CDD:293786
		ANK 3	114..143
		ANK 4	147..176
		Ank_2	152..251	CDD:289560	13/58 (22%)
		ANK repeat	158..219	CDD:293786	6/25 (24%)
		ANK	183..311	CDD:238125	38/158 (24%)
		ANK 5	188..217		6/23 (26%)
		ANK 6	220..249		6/29 (21%)
		ANK repeat	221..251	CDD:293786	6/30 (20%)
		SH3_Caskin2	284..345	CDD:212996	23/61 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..460		11/104 (11%)
		SAM_caskin1,2_repeat1	488..553	CDD:188896	15/65 (23%)
		SAM	494..549	CDD:197735	14/55 (25%)
		SAM_caskin1,2_repeat2	554..624	CDD:188897	21/118 (18%)
		SAM	560..621	CDD:197735	20/109 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..1104		12/58 (21%)
		Caskin-Pro-rich	798..883	CDD:293512
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1181
		Caskin-tail	1145..1202	CDD:293238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810