DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SKIP and sash3

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_690443.4	Gene:	sash3 / 561954	ZFINID:	ZDB-GENE-130411-1	Length:	386	Species:	Danio rerio

Alignment Length:	397	Identity:	116/397 - (29%)
Similarity:	180/397 - (45%)	Gaps:	70/397 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 LSPSPSSDYEDIGVTRGHGCLPPSLL-AAKAKKNGLPHGK-----ANTICQKATVHHSGEMRSSA 571
            :...|||.     ||.....|..||. ||..:::|..|||     .|.|.:..|...|..::.:.
Zfish    33 MKSKPSSP-----VTNPEPLLNESLFEAAPPEESGKSHGKLGKKWRNVITRTMTRKTSKMVQKAL 92

  Fly   572 KEIGAFNENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFACSASSVESLPS-----ASG-SSTQ 630
            .|.|  ||:|      :|.|....:..|.|...:..::...||.||.:::.|     .|| :..|
Zfish    93 AEEG--NESG------EDGSMSPMSPTDWTPDLTAGNRTSVCSNSSEDTIHSPLSRQLSGCADRQ 149

  Fly   631 ALVRPGSPHSSISAEDRTSMASCICKAKALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGR 695
            :|....|...|:..||.|.|.....:|..:.|..|:|||.:.||.:|||:|.::.....|.|.|:
Zfish   150 SLDSGFSQRDSMRLEDSTYMGPFCGRAVVITDFTPSPYDIDCLKLQKGDIIQIIEKPPVGTWTGK 214

  Fly   696 CHGRVGHFKFINVEVLPEQ----RMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLIRIGLKE 756
            .:.:||.|||:.|.:|||:    :.|.|.|             :|.....|.::|::|.||||.|
Zfish   215 LNNKVGSFKFVYVSMLPEEETPPKRKRSHS-------------HGHQKAKPKTLEEVLERIGLTE 266

  Fly   757 YTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSDVDIPGSSSENDEA 821
            ..|:..::|::.||.|..|:.:.|:.|.|.:.|.|.|:|.|.:|:||.|        ..|:.:|.
Zfish   267 LGSLLSMHGFQSLEDFTGLKESHLNDLNITDPEQRVKILKATELIHDSE--------DESDAEEQ 323

  Fly   822 RLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPTQAVNSTDESNSLDDVVTKCSS-----E 881
                           :...||||||||.:...:::.....|:|..|..:..|...|.::     |
Zfish   324 ---------------KTEMPRDSGCYESTENLANEREEPQVDSQAEPETDPDTEIKLNAVQEQLE 373

  Fly   882 IMKRVES 888
            :||..||
Zfish   374 VMKVEES 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	21/52 (40%)
		SAM	738..801	CDD:197735	22/62 (35%)
		SAM_superfamily	742..800	CDD:301707	22/57 (39%)
sash3	XP_690443.4	SLY	23..172	CDD:289268	42/151 (28%)
		SH3	174..229	CDD:302595	21/54 (39%)
		SAM_SASH-like	251..310	CDD:188892	22/58 (38%)
		SAM	252..311	CDD:197735	22/58 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11204
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6529
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12301
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5033
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.900