DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SKIP and sash3

DIOPT Version :9

Sequence 1:NP_001262827.1 Gene:SKIP / 42601 FlyBaseID:FBgn0051163 Length:1080 Species:Drosophila melanogaster
Sequence 2:NP_001016498.1 Gene:sash3 / 549252 XenbaseID:XB-GENE-1016821 Length:389 Species:Xenopus tropicalis


Alignment Length:409 Identity:117/409 - (28%)
Similarity:182/409 - (44%) Gaps:96/409 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   518 SSDYEDIGVTRGHGCLPPSLLAAKAK---KNGLPHGKANTICQKATVHHSGE------------- 566
            ||.::|.|.::     |.|.:.::.:   :|.:|..:|.....: ....||:             
 Frog    23 SSSFKDFGKSK-----PSSPVVSEKEFNLENDIPEDEAGVTADE-NKQSSGKLSKKWRAVISRTM 81

  Fly   567 --------MRSSAKEIGAFNENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFACSASSVESLPS 623
                    |::.|.|||            :.|.   .:|..:|| ||: |.....|:...|:|.|
 Frog    82 NRKMGKEVMKAMAHEIG------------EPTG---PSSPISTD-GSI-DGMHRKSSDPEENLHS 129

  Fly   624 ASGSSTQALVRPGSPHSSISAEDRTSMASC-------IC-KAKALVDSLPNPYDKEALKFKKGDL 680
            .....|.:.....||...|:..|..::.:.       .| |||...|.:|:|||.::||.||||:
 Frog   130 PVSRQTSSGSEVFSPSFMINNRDSINLENLPPPYNGPFCGKAKVHTDFIPSPYDGDSLKLKKGDI 194

  Fly   681 IDVLSMNASGIWKGRCHGRVGHFKFINVEVLPE--QRMKNSSSKTLAAGSRLANSGNGSHNGGPC 743
            ||::.....|.|.|....::|.||||.|:::||  :..|.:.::|.....|..          |.
 Frog   195 IDIIEKPPVGTWTGMLRNKIGSFKFIYVDLVPEETETPKKTKTRTKVRSKRQK----------PK 249

  Fly   744 SVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSD 808
            :|::||.||.::|:....:|||||.:|.||:|....|..|.|.:.:||.|||||.:.|.|.:   
 Frog   250 TVQELLERINMQEHIPTLLLNGYETIEDFKDLSENHLIELNITDPQHRVKLLTAAEFLLDYD--- 311

  Fly   809 VDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPTQAVNSTDESN--SL 871
                 :.||. |...:..:|:|..      |.||||||||||        ....||.|::.  |:
 Frog   312 -----TGSET-EGMTDTSSMEHSI------HIPRDSGCYEGS--------ENLENSRDDNEIISI 356

  Fly   872 D-DVVTKC---SSEIMKRV 886
            | |:...|   |:|:...|
 Frog   357 DEDIKNLCLVESTEVKHAV 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SKIPNP_001262827.1 SAM_Samd5 4..65 CDD:188926
SAM 7..65 CDD:197735
SH3 657..710 CDD:302595 24/52 (46%)
SAM 738..801 CDD:197735 26/62 (42%)
SAM_superfamily 742..800 CDD:301707 26/57 (46%)
sash3NP_001016498.1 SLY 19..167 CDD:372142 32/166 (19%)
SH3_SASH3 169..224 CDD:212901 25/54 (46%)
SAM_SASH-like 247..306 CDD:188892 26/68 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 56 1.000 Domainoid score I10828
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm9435
Panther 1 1.100 - - O PTHR12301
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5033
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.040

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