DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SKIP and samsn1b

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_005169221.1	Gene:	samsn1b / 450018	ZFINID:	ZDB-GENE-041010-135	Length:	676	Species:	Danio rerio

Alignment Length:	764	Identity:	185/764 - (24%)
Similarity:	292/764 - (38%)	Gaps:	199/764 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 PIVPGQQQQGPHQHQTLPPNVAH---LNFVQQNCLSPRSAYFYEFPPTAEGRETKKRTTLARLLK 244
            |...||..|.....:...||.|.   |....:.|::.:.       |.....:|::..||.:..|
Zfish    18 PAQIGQSSQDSLPRRPFSPNCAKNMGLWSGSEPCIATKL-------PETHTSKTRESKTLEKAKK 75

  Fly   245 --GLKTVNRRDRNNQQNGAQARAANDRLRHFQMINGGAGGQQHSFEETI---HRLKVQEAMRKKE 304
              .|::.: .|......|:.|...:.|.:     :|...|:.||..|..   ||.|:   :.::|
Zfish    76 KSQLQSTS-EDETTDHTGSDAHWPSTRKK-----DGLVNGKNHSAAEAAKDHHRSKL---LSREE 131

  Fly   305 KFQREHEE--ILRDIRQGL------LQMSRGEGRMDD----TYMYDEALRTGGGMGIAGLGMPLG 357
            |.:|.:.|  :.....||:      ......|.|..|    :.:.|||  .|....|..|
Zfish   132 KEERGNSEKAVKNPCGQGVNFEAWNPNRENSECRQQDLARRSEVEDEA--QGTLKKIQKL----- 189

  Fly   358 VGGNGGGGGAAHYAVSALHHQGHWYDEPPYESDPDDFLMAGLNCGPAATIQGGRVRFSNNRESTG 422
            |||..||..:.....:                               :|...|.:..||::..:.
Zfish   190 VGGKKGGQNSMEEMRN-------------------------------STEAAGNLTESNSKHHSP 223

  Fly   423 VISLRSAGDISLPQRGPPRRGLIVPQQPPNPPTI---IPLTHARSHDRESGDYAGSIS-----DL 479
            ||:.     |||.::...:     |.:.|:.||.   .||....:......:|...::     |.
Zfish   224 VITC-----ISLTKKAEKK-----PTRAPSRPTAQSQQPLQENDTLPELFYEYYSPVAFSPAWDT 278

  Fly   480 QSVTSRFSTV---------SIGTNNCTARYRTLSGGIGESPSLSPSPSSDY-EDIGVTRGHGCL- 533
            .:.|...||.         ::..:....||..|...:        .|...| :|..:|  |..:
Zfish   279 STHTCHRSTAEQVMYNFNFTLPRDTDWDRYEDLFQRL--------DPYKRYQQDTWIT--HSVME 333

  Fly   534 ------------------PPSLLAAKAKKNGLPHGKANTICQKATVHHSGEMRSSAKEIGAF--N 578
                              .|:.:.|:.|...||.........|     ||.:....|.|...  .
Zfish   334 LDKPDALRSTSFGIFDRQQPNQVKAEDKVESLPVESPEVDPSK-----SGGLSKKMKNISLTMRK 393

  Fly   579 ENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFA----CSASSVESLPSA-SGSSTQALVRPGSP 638
            :.||.:  ||..|.: :..::......:.|...|    .|::|||||.|. ||.|:.:.|..||.
Zfish   394 KMGRKY--TKALSEE-TGEENEAAAADVVDGTLAKGNNHSSNSVESLFSLHSGQSSSSGVTSGSE 455

  Fly   639 ----HSSISAEDRTSMASCIC-KAKALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGRCHG 698
                ..|:..|:....|...| |||...|.:|:|||.|:||.|.||:||:::....|||.|..:|
Zfish   456 GYSNRDSLRLEEEVPFAGQFCGKAKVHTDFVPSPYDTESLKLKVGDVIDIINKPPMGIWTGMLNG 520

  Fly   699 RVGHFKFINVEVL-----PEQRMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLIRIGLKEYT 758
            :||:||||.|:||     |:.|::               :...|....|.::::||.|:.|:|:.
Zfish   521 KVGNFKFIYVDVLVEEITPQPRIR---------------AHRRSRRPRPKTLQELLERLNLEEHI 570

  Fly   759 SVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSDV------DIPGSSSE 817
            |..:||||:.:|..::|:...|..|.:.:.|||.:||.|.:.|.|.|.::.      :.|.|.||
Zfish   571 SSLLLNGYQTVEDLRDLKEQHLVELNMTDPEHRHRLLAAAENLLDSEYNNQSHGETNEEPKSPSE 635

  Fly   818 NDEARLNNINMKHGASPFGRRHFPRDSGCYEGS--------PLPSSQTP 858
            .::..||:.              |||||||.||        ...|.|||
Zfish   636 EEKIELNDC--------------PRDSGCYIGSDCSDNSKEDTESQQTP 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	27/52 (52%)
		SAM	738..801	CDD:197735	21/62 (34%)
		SAM_superfamily	742..800	CDD:301707	21/57 (37%)
samsn1b	XP_005169221.1	SLY	341..475	CDD:289268	33/141 (23%)
		SH3_SASH_like	478..529	CDD:212756	26/50 (52%)
		SAM_superfamily	554..615	CDD:301707	22/60 (37%)
		SAM	<569..616	CDD:197735	16/46 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11204
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6529
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12301
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5033
SonicParanoid	1	1.000	-	-		X5009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	7.000