DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SKIP and samsn1a

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001122141.1	Gene:	samsn1a / 336695	ZFINID:	ZDB-GENE-030131-8639	Length:	621	Species:	Danio rerio

Alignment Length:	827	Identity:	177/827 - (21%)
Similarity:	300/827 - (36%)	Gaps:	267/827 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SLSGSMEILCETPPNNELELVLREQLETDGVRLTAHPYSTPPSSCLSDKEEDEIYGFGYGVFAPR 144
            ||.|||:.|.|         .:::..|       |..|:.|..||                 :|.
Zfish     7 SLEGSMDSLYE---------AVQDSCE-------AQVYTIPSRSC-----------------SPA 38

  Fly   145 VARGGLTQQQQLLQQQTLQTQQSIQQQQQQMQQQQQQLPIVPGQQQQGPHQHQTLPPNVAHLNFV 209
            |          ||:..| :.:.:.:....:|.|      |.|..:::   :.::||.:|:. |..
Zfish    39 V----------LLEDNT-KRRSAGRSCSMEMSQ------INPDNRKK---KQRSLPKSVSE-NDT 82

  Fly   210 QQNCLSPRSAYFYEFPPTAEGRETKKRTTLARLLKGLKTVNRRDRNNQQNGAQ--ARAANDRLRH 272
            ..|.|...|.:     |.|     ||:..|..|           ||||....:  .|..|..:.:
Zfish    83 SDNTLGTNSVW-----PAA-----KKQEDLVLL-----------RNNQNEDLRRAVRTENQTMAN 126

  Fly   273 FQMIN----------------------GGAGGQQHSFEETIHRLKVQEAMRKKEKFQREHEEILR 315
            .::|.                      .|...:|:...||::...::....:.:|.:::..:  |
Zfish   127 LKIIARNPQQESQPIQVVYYEGCKPNLDGLSSRQNGVTETVNEEMIRARGTRVKKLEKKSSQ--R 189

  Fly   316 DI-RQGLLQMSRG-EGRMDDTYMYDEALRTGGGMGIAGLGMPLGVGGNGGGGGAAHYAVSALHHQ 378
            :. .|.....|:| :|.|.|..|:.:
Zfish   190 ETPTQETTDPSKGAKGTMPDVGMWSQ--------------------------------------- 215

  Fly   379 GHWYDEPPYESDPDDFLMAGLNCGPAATIQGGRV---------RFSNNRESTGVISLRSAGDISL 434
                       :||      ::|    |.:|.||         |:||..|||.|.:..
Zfish   216 -----------NPD------ISC----TSEGLRVKQIAASSRNRWSNPTESTWVQAYN------- 252

  Fly   435 PQRGPPRRGLIVPQQPPNPPTIIPLTHARSH--------DRESGD-YAGSISDLQSVTSRFSTVS 490
                        |.||       .|:..|.|        :|..|| ..|......|:.......:
Zfish   253 ------------PCQP-------QLSEHRIHTCECTASRNRSQGDKINGPNMKRDSLPKGMMRST 298

  Fly   491 IGTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTRGHGCLPPSLLAAKAKKNGLPHGKANTI 555
            ...:.|.:: |:.|.|..::.....|||                      |.::||.|..:.:
Zfish   299 TSVDFCASK-RSTSFGRFDTFRNQNSPS----------------------KLEENGTPETEGD-- 338

  Fly   556 CQKATVHHSGEMRSSAKEIGAFNENGRNFVA---TKDTSRDFS-NSQDNTDRGSMSDQAFACSAS 616
               :....|.:.|...|::.|.:...|..:.   .|..|.|.: :::..|:.||..:::...:::
Zfish   339 ---SAADISEKPRCLGKKMKAISMTMRKRMGKKPVKSCSEDMADDTEGETENGSAVEKSSDRTSN 400

  Fly   617 SVESLPSASGSSTQALVRPGSPHS----SISAEDRTSMASCIC-KAKALVDSLPNPYDKEALKFK 676
            |:|||.|...||:...|...|..|    |:..|:........| :||...|.:|:|||.::||.|
Zfish   401 SLESLYSGQSSSSSGGVASSSDVSSNRDSLKLEEEALYTGQFCGRAKVHTDFVPSPYDTDSLKLK 465

  Fly   677 KGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGSHNGG 741
            .||:|.::|....|||.|..:.:||:||||.|:||||:..:...........::.....
Zfish   466 VGDIISIISKPPMGIWTGMLNNKVGNFKFIYVDVLPEKEKEQEEEAPKIRPMKVCKKPR------ 524

  Fly   742 PCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIEC 806
            |.::.:||.|:.|:||.|..:||||:.::..:.|:...|..|.:.:.|||.:||.|...|:   .
Zfish   525 PNTLLELLERLHLEEYASSLLLNGYQTVDDLRHLKERHLIELNVTDPEHRHRLLAASDCLY---V 586

  Fly   807 SDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLP 853
            ::.:..|....:||...|:     |.         |||||:..:..|
Zfish   587 TNKEEEGEMKGDDEDEDND-----GL---------RDSGCFIPAECP 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	25/52 (48%)
		SAM	738..801	CDD:197735	21/62 (34%)
		SAM_superfamily	742..800	CDD:301707	21/57 (37%)
samsn1a	NP_001122141.1	SLY	307..442	CDD:289268	33/162 (20%)
		SH3_SASH_like	445..496	CDD:212756	23/50 (46%)
		SAM_superfamily	521..584	CDD:301707	21/68 (31%)
		SAM	<540..584	CDD:197735	15/43 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11204
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6529
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12301
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5033
SonicParanoid	1	1.000	-	-		X5009
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.900