DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SKIP and Sash3

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_006257592.1	Gene:	Sash3 / 317578	RGDID:	1560293	Length:	381	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	113/374 - (30%)
Similarity:	164/374 - (43%)	Gaps:	65/374 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 ESPSLSPSPSSDYEDIGVTR--------------------GHGCLPPSLLAAKAKKNGLPHGKAN 553
            :...||...||.::|...::                    ..|.|.|.......||.|   .|..
  Rat    16 QKKKLSLQRSSSFKDFAKSKPSSPVVSEKEFNLDDNIPEDDSGVLTPEDSGKSGKKLG---KKWR 77

  Fly   554 TICQKATVHHSGEM--RSSAKEIGAFNENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFACSAS 616
            .:..:......|:|  ::.::|:|...|.|.....:.|.|.|           |...:..|.:.|
  Rat    78 AVISRTMNRKMGKMMVKALSEEMGDTLEEGSASPTSPDCSLD-----------SPGPEKMALAFS 131

  Fly   617 SVE-------SLPSASGSSTQALVRPGSPHSS-ISAEDRTSMASCIC-KAKALVDSLPNPYDKEA 672
            ..|       |..:::||.   |..||....| |............| :|:...|..|:|||.::
  Rat   132 EPEERELLALSRQTSTGSE---LCSPGPGSGSFIEESPAPQYTGPFCGRARVHTDFTPSPYDHDS 193

  Fly   673 LKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGS-RLANSGNG 736
            ||.:|||:|.::.....|.|.|..:|::|.||||.|:||||:          |.|. |.:...:.
  Rat   194 LKLQKGDVIQIIEKPPVGTWLGLLNGKLGSFKFIYVDVLPEE----------AVGPVRPSRRQSK 248

  Fly   737 SHNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLL 801
            |....|.::.:||.||||:|:||..:||||:.||.||||....|:.|.|::.:||||||||.:||
  Rat   249 SKRPKPKTLHELLERIGLEEHTSTLLLNGYQTLEDFKELRETHLNELNIMDPQHRAKLLTAAELL 313

  Fly   802 HDIECSDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGS 850
                 .|.|..||....:.|..:.....|..|. .:...||||||:|||
  Rat   314 -----LDYDTAGSEEAEEGAESSQEPALHTVSE-PKVDIPRDSGCFEGS 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	22/52 (42%)
		SAM	738..801	CDD:197735	31/62 (50%)
		SAM_superfamily	742..800	CDD:301707	31/57 (54%)
Sash3	XP_006257592.1	SLY	21..174	CDD:289268	32/169 (19%)
		SH3_SASH3	176..231	CDD:212901	22/54 (41%)
		SAM_superfamily	250..317	CDD:301707	34/71 (48%)
		SAM	252..316	CDD:197735	33/68 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11150
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44859
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12301
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.870