Protein Alignment SKIP and SASH1

DIOPT Version :9

• Sequence 1: NP_001262827.1
• Gene: SKIP / 42601
• FlyBaseID: FBgn0051163
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: XP_016866087.1
• Gene: SASH1 / 23328
• HGNCID: 19182
• Length: 1410
• Species: Homo sapiens
• Alignment Length: 1210
• Identity: 258/1210 - (21%)
• Similarity: 407/1210 - (33%)
• Gaps: 410/1210 - (33%)

  Fly    29 DDLEICKQVGDPDLDAIGVENPAHRHKLLKSIRSLREKGAASVYFMLNDPNSLSGSM-------- 85
            :.|..|..|..|:::.   :||.|:.....|.....:....:.||..|...:..|.|
Human   113 ESLGFCSAVSTPEVER---KNPLHKSNSEDSSVGKGDWKKKNKYFWQNFRKNQKGIMRQTSKGED 174

  Fly    86 ------EILCETPPNNELELVLREQLET---------------------------DGVRLTAHPY 117
                  ||........:|.::::|::.|                           ||    ::|.
Human   175 VGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSAALDPADWPDG----SYPT 235

  Fly   118 STPPSSC----LSDKEEDEIYGF---GYGVFAPRVARGGLTQQQQLLQQQTLQTQQSIQQQQQQM 175
            ....|:|    .||.|.:|...|   ...|.:.|..|..|.:.:::.:..|...::.:.:....:
Human   236 FDGSSNCNSREQSDDETEESVKFKRLHKLVNSTRRVRKKLIRVEEMKKPSTEGGEEHVFENSPVL 300

  Fly   176 QQQQ------QQLPI-VPGQQQQGPHQHQ---TLPPNVAHLNF--------------VQQNCLSP 216
            .::.      .:.|: ..|..::.|....   |..|:.:.|:.              ..:..:.|
Human   301 DERSALYSGVHKKPLFFDGSPEKPPEDDSDSLTTSPSSSSLDTWGAGRKLVKTFSKGESRGLIKP 365

  Fly   217 --RSAYFYEFPPTAEGRETKKRTTLARLLKGLKTVNRRDRNNQQNGAQARAA----NDRLRHFQM 275
              :...|:.:|...:.::..:..|...:.|||.:::        :|......    |.|.||..:
Human   366 PKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGSLS--------HGVSTDGVCFYDNHRRRHHLL 422

  Fly   276 INGGAGGQQHSFEETIHRLKVQEAMRKKEKFQREHEE--------ILRDIRQGL------LQMSR 326
            :         |.||.       :::||:.:.::....        ..|..|:|:      ||:.|
Human   423 V---------SLEEF-------QSVRKQIRLKKTDTNYSCSRAFLCQRPSRKGVTSTTCDLQLLR 471

  Fly   327 GEGRMDDTYMYDEALRTGGGMGIAGLGMPLGVGGNGGGGGAAHYAVSALHHQGHWYDEPPYESDP 391
            .:|:                                 |||
Human   472 QKGK---------------------------------GGG------------------------- 478

  Fly   392 DDFLMAGLNCGPAATIQGGRVRFSNNRESTGVISL------------------RSAGD--ISLPQ 436
                    :||    ..|.|||   .|.|....::                  |.|.|  :|..:
Human   479 --------SCG----FPGRRVR---GRTSVSEFNITYVVERSLYSHLNLTQLVRPASDRTLSKAE 528

  Fly   437 RGPPRRGLIVPQQPPN----------PPTIIPLTHARSHDRESGDYAGSISDLQSVTSRFSTVSI 491
            |...||.|:...:...          ...::...|.:|.....|.:        .:|:|  ::.:
Human   529 RQDLRRCLLEEDEEAKRKWAATVDRCTKRVLLRIHQKSRTCSFGGF--------DLTNR--SLHV 583

  Fly   492 GTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTRGHGCLPPSLLAAKAKKNGLPHGKANTIC 556
            |:||                       ||                           |.||.....
Human   584 GSNN-----------------------SD---------------------------PMGKEGDFV 598

  Fly   557 QKATVHHSGEMR-SSAKEIGAFNENGRNFVATKDTSRDFSNSQDNTDRG---------------S 605
            .|..:......| |..|::.:..|..|     |..|:.:|:|....|.|               .
Human   599 YKEVIKSPTASRISLGKKVKSVKETMR-----KRMSKKYSSSVSEQDSGLDGMPGSPPPSQPDPE 658

  Fly   606 MSDQAFACSASSVESLPSA-------SGSSTQALVRPGSPHSSISAED----RTSMASCIC-KAK 658
            ..|:....:..|||||.|:       ||.:........|...|:.:||    ........| :|:
Human   659 HLDKPKLKAGGSVESLRSSLSGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRAR 723

  Fly   659 ALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKT 723
            ...|..|:|||.::||.||||:||::|....|.|.|..:.:||.||||.|:||.|...|....
Human   724 VHTDFTPSPYDTDSLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLSEDEEKPKRP-- 786

  Fly   724 LAAGSRLANSGNGSHNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQ 788
                :|....|....   |.||||||.||.|||:...|:.||||||:.||.||..|||.|.|.:.
Human   787 ----TRRRRKGRPPQ---PKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDP 844

  Fly   789 EHRAKLLTAVQLLHDIECSDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGS--- 850
            ||||.|||||:||.:.: |:.|..||    .|..|.:.....|.|       ||||||||.|
Human   845 EHRAVLLTAVELLQEYD-SNSDQSGS----QEKLLVDSQGLSGCS-------PRDSGCYESSENL 897

  Fly   851 --------PLPSSQTPTQAVNSTDESNSLDDVVTKCSSEIMKRVESARRCKDNPFKTTLPGGGRL 907
                    .|.|:::.|:....:...|.|.:..|   ..:||..::.::.::.         |||
Human   898 ENGKTRKASLLSAKSSTEPSLKSFSRNQLGNYPT---LPLMKSGDALKQGQEE---------GRL 950

  Fly   908 GKKSFLGGNGLMADDTLTRGGLSEKSSD-SGVSSSSLSSGPLKSSTXHLPTILAH--ELLLGVGS 969
            |     ||   :|.||       .||.| .||:.       |..:...||..:..  |.|.|..:
Human   951 G-----GG---LAPDT-------SKSCDPPGVTG-------LNKNRRSLPVSICRSCETLEGPQT 993

  Fly   970 GMGMGLGLGTMSHGTTGTLTPHGVATATSPTAHSAPLGNICNTLPHAPSSSGGGGVSSSMASNLP 1034
                 :.....||.........| |....||..:.|...|   :|..|..:     ::|.....|
Human   994 -----VDTWPRSHSLDDLQVEPG-AEQDVPTEVTEPPPQI---VPEVPQKT-----TASSTKAQP 1044

  Fly  1035 LNR-----NLVMLRNHLRKNTGGSITG---NGGVGASGVG 1066
            |.:     |.::|....|.:....:|.   .|.:.|||.|
Human  1045 LEQDSAVDNALLLTQSKRFSEPQKLTTKKLEGSIAASGRG 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926	8/35 (23%)
		SAM	7..65	CDD:197735	8/35 (23%)
		SH3	657..710	CDD:302595	25/52 (48%)
		SAM	738..801	CDD:197735	37/62 (60%)
		SAM_superfamily	742..800	CDD:301707	37/57 (65%)
SASH1	XP_016866087.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9367
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40721
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12301
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.870