DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SKIP and Samsn1

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_570834.2	Gene:	Samsn1 / 170637	RGDID:	620926	Length:	372	Species:	Rattus norvegicus

Alignment Length:	386	Identity:	111/386 - (28%)
Similarity:	180/386 - (46%)	Gaps:	71/386 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   512 SLSPSPSS-DYEDIGVTRGHGCLPPSLLAAKAKKNGLPHGKANTICQKATVHHSGEMRSSAKEIG 575
            |:|.|..| :..|..:|.|      |...:|...||...||     :...:..:.:.:...|.|.
  Rat    34 SISKSDDSIEVRDGELTNG------SEEQSKTSNNGGSLGK-----KVRAISWTMKKKVGKKYIK 87

  Fly   576 AFNENGRNFVATKDTSRDFSNSQDNTDRGSMSDQAFACSASSVESLPSASGSSTQALVRPG---- 636
            |.:|.....:  ::.:..:.||....  |:.:::....::.|::||.|...||:      |
  Rat    88 ALSEEKEEEI--REETLQYRNSDPMI--GTRTEKISLKASDSMDSLYSGQSSSS------GITNC 142

  Fly   637 ----SPHSSISAEDRTSMASCIC-KAKALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGRC 696
                |...|...:|.:..:...| :|:...|..|:|||.::||.||||:||::.....|:|.|..
  Rat   143 SDGTSNRDSFRLDDDSPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGML 207

  Fly   697 HGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLIRIGLKEYTSVF 761
            :.:||:||||.|:|:.|:.          |..:.......|....|.::::.|.||.|:||||.|
  Rat   208 NNKVGNFKFIYVDVISEEE----------AAPKKVKVPRSSRRENPQTLQEFLERIHLQEYTSAF 262

  Fly   762 VLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECS----DVDIPGSSSEN--DE 820
            :|||||.|:..|:::.:.|..|.|.|.|.||:||:|.:.|.|.|.:    :..:|.||:.:  .|
  Rat   263 LLNGYEALDDLKDIKESHLIELNIANPEDRARLLSAAESLLDEETAAEHEEEPVPLSSNPDILSE 327

  Fly   821 ARLNNINMKHGASPFGRRHFPRDSGCY--EGSPLPSSQTPTQAVNSTDESNSLDDVVTKCS 879
            ::|::.              |||||||  .|:.....:.|        ||.||.|:|.|.|
  Rat   328 SQLDDC--------------PRDSGCYISSGNSDNGKEDP--------ESQSLPDMVQKIS 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	24/52 (46%)
		SAM	738..801	CDD:197735	27/62 (44%)
		SAM_superfamily	742..800	CDD:301707	27/57 (47%)
Samsn1	NP_570834.2	SLY	17..164	CDD:289268	30/150 (20%)
		SH3	167..218	CDD:302595	22/50 (44%)
		SAM_SAMSN1	239..304	CDD:188960	28/64 (44%)
		SAM	243..304	CDD:197735	28/60 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11150
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44859
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12301
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5009
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010