DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SKIP and Caskin2

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_542374.2	Gene:	Caskin2 / 140721	MGIID:	2157062	Length:	1201	Species:	Mus musculus

Alignment Length:	853	Identity:	174/853 - (20%)
Similarity:	256/853 - (30%)	Gaps:	283/853 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AVSNIVCEWLRALGLAQYAESFLDNGYDDLEICKQVGDPDLDAIGVENPAHRHKLLKSIRSLREK 66
            |:.|    ||....|..|...||..|||...|.:...: ||.||||..|.||.|:...|..|
Mouse   492 AIHN----WLSEFQLEGYTAHFLQAGYDVPTISRMTPE-DLTAIGVTKPGHRKKIASEIAQL--- 548

  Fly    67 GAASVYFMLNDPNSLS-GSMEILCETP-PNNELELVLR-------------EQLETDGVRLTAHP 116
               |:...|  ||.:. ..:|.||... |....:||..             |:|:..||....|.
Mouse   549 ---SIAEWL--PNYIPVDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQ 608

  Fly   117 YSTPPS-SCLSDKEEDEIYGFGYGVFAPRVARGGLTQQQQLLQQQTLQTQQSIQQQQQQMQQQQQ 180
            ...... ..|::.....::|...|....|:.||     .:|:..:.|:..:
Mouse   609 KKLMLGVKRLAELRRGLLHGEALGEGGRRMTRG-----PELMAIEGLENGE-------------- 654

  Fly   181 QLPIVPGQQQQGPH----QHQTLPPNVAHLNFVQQNCLSPRSAYFYEFPPTAEGRETKKRTTLAR 241
                  |....||.    |...|.|.:       |..::...:.....||.
Mouse   655 ------GPTTAGPRLLTFQGSELSPEL-------QAAMAGGGSEPLPLPPA-------------- 692

  Fly   242 LLKGLKTVNRRDRNNQQNGAQARAANDRLRHFQMINGGAGGQQHSFEETIHRLKVQEAMRKKEKF 306
                      |..:.:..||::|                 |..||.|:.:.:..|.:....:|
Mouse   693 ----------RSPSQESIGARSR-----------------GSGHSQEQPVPQPSVGDPSAPQE-- 728

  Fly   307 QREHEEILRDIRQGLLQMSR------GEGRMDDTYMYDEALRTGGGMGIAGLGMPLGVG---GNG 362
                    |::.:|..:.|:      |:|.....:|..:.|.:.     ...|.|.||.   ...
Mouse   729 --------RNLPEGTERPSKLCSPLPGQGPAPYVFMCPQNLPSS-----PAPGPPPGVPRAFSYL 780

  Fly   363 GGGGAAHYAVSALHHQGHWYDEP-PYESDPDDFLMAGLNCGPAATIQGGRVRFSNNRESTGVISL 426
            .|..||.........:.|....| |.|.:.:     |...||..:..|.   ::......|..:|
Mouse   781 AGSPAAPPDPPRPKRRSHSLSRPGPAEGEAE-----GEAEGPVGSALGS---YATLTRRPGRSTL 837

  Fly   427 RSAGDISLPQRGPP----------RRGLIVPQQPPNPP----TIIPLTHARSHDRESGDYAGSIS 477
            ........|.||.|          |:|     .||.||    ::...|...|.|..||...|:..
Mouse   838 ARTSPSLTPTRGTPRSQSFALRARRKG-----PPPPPPKRLSSVSGSTEPPSLDGTSGPKEGATG 897

  Fly   478 DLQSVTSRFSTVSIGTNNCTARYRTLSGGIGESPSLSPS----PSSDYEDIGVTRGHGCLPPSLL 538
                                .|.||||...|.|.|..||    |.||.|:.....|   .|||
Mouse   898 --------------------PRRRTLSEPTGPSESPGPSAPTGPVSDTEEEPGPEG---TPPS-- 937

  Fly   539 AAKAKKNGLPHGKANTICQKATVHHSG----------------------EMRSSAKE-------- 573
             ..:...|||..:...:..|.....:|                      :.|...||
Mouse   938 -RGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVPPGLDFNLTESDTVKRRPKCKEREPLQTAL 1001

  Fly   574 -----IGAFNENGRNFVATK---DTSRDFSNSQDNTDRGSMSDQAFACSASSVESL--------P 622
                 :|:......|.::|:   |.....||....::...:..|  ..||||:.|:        |
Mouse  1002 LAFGVVGSDTPGPSNPLSTQAPCDPPSASSNPPQRSEPSVLPSQ--GTSASSLSSVTQSPGHPGP 1064

  Fly   623 SA-------SGSSTQALVRPGSPHSSI----SAEDRTSMASCICKAKA-----LVDSL-PNPYDK 670
            ||       :||.......|.:|.:::    .|.......|..|...|     |...| |.|...
Mouse  1065 SAGPALANSTGSKPNVETEPPAPPAALLKVPGAGTAPKPVSVACTQLAFSGPKLAPRLGPRPVPP 1129

  Fly   671 EALKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGN 735
            ...:            |...:    |.||.            :||::.:|| :|.|..|.|....
Mouse  1130 PRPE------------NTGPV----CPGRA------------QQRLEQTSS-SLEAALRAAEKSI 1165

  Fly   736 GS-HNGGP 742
            |: ...||
Mouse  1166 GTEERDGP 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926	23/60 (38%)
		SAM	7..65	CDD:197735	22/57 (39%)
		SH3	657..710	CDD:302595	9/58 (16%)
		SAM	738..801	CDD:197735	2/5 (40%)
		SAM_superfamily	742..800	CDD:301707	1/1 (100%)
Caskin2	NP_542374.2	ANK	7..135	CDD:238125
		Ank_4	7..61	CDD:290365
		ANK repeat	7..46	CDD:293786
		ANK repeat	48..79	CDD:293786
		ANK 1	48..77
		Ank_2	53..145	CDD:289560
		ANK	76..209	CDD:238125
		ANK 2	81..110
		ANK repeat	85..112	CDD:293786
		ANK repeat	114..145	CDD:293786
		ANK 3	114..143
		ANK 4	147..176
		Ank_2	152..251	CDD:289560
		ANK repeat	158..219	CDD:293786
		ANK	183..311	CDD:238125
		ANK 5	188..217
		ANK 6	220..249
		ANK repeat	221..251	CDD:293786
		SH3_Caskin2	284..345	CDD:212996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..466
		SAM_caskin1,2_repeat1	487..552	CDD:188896	25/70 (36%)
		SAM	493..548	CDD:197735	22/59 (37%)
		SAM_caskin1,2_repeat2	553..623	CDD:188897	15/71 (21%)
		SAM	561..620	CDD:197735	12/58 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..1103		99/531 (19%)
		Caskin-Pro-rich	797..881	CDD:293512	20/96 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1115..1179		19/88 (22%)
		Caskin-tail	1144..1201	CDD:293238	11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810