Protein Alignment SKIP and SKIP

DIOPT Version :10

• Sequence 1: NP_001262827.1
• Gene: SKIP / 42601
• FlyBaseID: FBgn0051163
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: XP_061496559.1
• Gene: SKIP / 1273929
• VectorBaseID: AGAMI1_009562
• Length: 1234
• Species: Anopheles gambiae
• Alignment Length: 1305
• Identity: 646/1305 - (49%)
• Similarity: 725/1305 - (55%)
• Gaps: 428/1305 - (32%)

  Fly     1 MAVSNIVCEWLRALGLAQYAESFLDNGYDDLEICKQVGDPDLDAIGVENPAHRHKLLKSIRSLRE 65
            ||||||||||||||||.||||||||||||||||||||||||||||||:|||||.|||||:|.|||
Mosquito     1 MAVSNIVCEWLRALGLGQYAESFLDNGYDDLEICKQVGDPDLDAIGVQNPAHRSKLLKSVRLLRE 65

  Fly    66 KGAASVYFMLNDPNSL----SGSMEILCETPPNNELELVLREQLETDGVRLTAHPYSTP------ 120
            ||||||||.||||.||    |.|:|........:|||.:|:|||:.|||.|||||||||
Mosquito    66 KGAASVYFQLNDPKSLLSDNSDSLERDSSPLMLSELEALLQEQLKADGVCLTAHPYSTPDGARGH 130

  Fly   121 ----------------------------------------------------------------- 120
                                                                             
Mosquito   131 LEGLASVYCEMLLAPFGEVLSALEEARQRAWSERSPHSSSGGGGLIRGHRGNSCHGGLPNSHSQP 195

  Fly   121 --------PSSCLSDKEEDEIYGFGYGVFAPRVARGGLTQQQQLLQQQTLQTQQSIQQQQQQMQQ 177
                    |||||||||||||||||||||||||||..|..||....||        ||||||.||
Mosquito   196 IYVPGKYSPSSCLSDKEEDEIYGFGYGVFAPRVARTTLQSQQAQPGQQ--------QQQQQQQQQ 252

  Fly   178 QQQQLPIVPGQQQQGPHQHQT---LPPNVAHLNFVQQNCLSPRSAYFYEFPPTAEGRET-KKRTT 238
            ||||      ||||.|.|.||   :|.|.|   .|||:||||||||||||||| :|||| |||||
Mosquito   253 QQQQ------QQQQQPQQSQTSANVPANSA---AVQQSCLSPRSAYFYEFPPT-DGRETSKKRTT 307

  Fly   239 LARLLKGLKTVNRRDRNNQQ----NGAQARAANDRLRHFQMINGGAGGQQHSFEETIHRLKVQEA 299
            |||||:||||||||||:||.    ...|:|:.|:||||||| ||  ||.|.||||||.|||:|||
Mosquito   308 LARLLRGLKTVNRRDRSNQNTTGGTATQSRSQNERLRHFQM-NG--GGPQPSFEETIQRLKIQEA 369

  Fly   300 MRKKEKFQREHEEILRDIRQGLLQMSRGEGRMDDTYMYDEALRTGGGMGIAGLGMPLGVGGNGGG 364
            :|||||||||||||||||||||||:||..  .|||||||:|:..       .:.||
Mosquito   370 LRKKEKFQREHEEILRDIRQGLLQLSRDS--RDDTYMYDDAVTN-------VMRMP--------- 416

  Fly   365 GGAAHYAVSALHHQGHWYDEPPYESDPDDFLMAGL------------------NCGPAATIQGGR 411
                       |||||||||||||||||||||:|:                  ..||:|||||||
Mosquito   417 -----------HHQGHWYDEPPYESDPDDFLMSGMRQIGAAGYAGDGGGGGDGGGGPSATIQGGR 470

  Fly   412 VRF-SNNRES-TGVISLRSAGDISLPQRGPPRRGLIVPQQPPNPPTIIPLTHARSHDRESGDYAG 474
            |.: :|.||. ..|||||||||||:|||| ||||||||||||||||||||.||||||||||||||
Mosquito   471 VCYTTNGREGPQSVISLRSAGDISIPQRG-PRRGLIVPQQPPNPPTIIPLKHARSHDRESGDYAG 534

  Fly   475 SISDLQSVTSRFSTVSIGTNNCTARYRTLSGGIG-ESPSLSPSPSSDYEDI-------------- 524
            |||||.|||||.|.||||.|||||||||||.|:| ||||.||:|||:|:||
Mosquito   535 SISDLHSVTSRLSQVSIGMNNCTARYRTLSAGLGDESPSPSPTPSSEYDDILQANALQLQKHLHH 599

  Fly   525 -----------------GVTRG-----HGCLP--------------------------------- 534
                             |.|.|     ..||.
Mosquito   600 HQQLKRLDGGMVGPGQPGSTSGLIGSAASCLVGPAGSSAAVAAAAATVGNSSVGNTSGTVGGSIA 664

  Fly   535 -----------PSLL-------------------------------------------------- 538
                       ||:|
Mosquito   665 LASGGASGANLPSVLGGTGGAGTDISSASTSNSTATTGGSSGNSSSSASSNNSTSTKNTVNNLKS 729

  Fly   539 --AAKAKKN---------------GLPHGKAN-TICQK-ATVHHSGEMRSSAKEIGAFNENGRNF 584
              |||.:.|               .:.|...| :|.|: |.||||.:.|:|.|:...:....|
Mosquito   730 LKAAKNRNNLTSSLAAASAASSAAAVSHNNKNLSISQQIALVHHSNDARTSPKDHLLYGGKDR-- 792

  Fly   585 VATKDTSRDFSNSQDNTDRGSMSDQAFACSASSVESLPSASGSSTQALVRPGSPHSSISAEDRTS 649
                 ::||:||..|     |:|||.|..||||||||||||||||||||||||||||:||||||:
Mosquito   793 -----SNRDYSNCLD-----SISDQTFQHSASSVESLPSASGSSTQALVRPGSPHSSLSAEDRTT 847

  Fly   650 MASCICKAKALVDSLPNPYDKEALKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPE- 713
            |.. ||:|.|||||.|:|||||||:|||||:||||||||||:|:|..:||:||||||:|||||:
Mosquito   848 MLP-ICRAIALVDSCPSPYDKEALRFKKGDIIDVLSMNASGVWRGYANGRLGHFKFISVEVLPDL 911

  Fly   714 --QRMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELE 776
              ..:|....| |.:..||..|       .|.|||:||:||||||||||||||||||||||||||
Mosquito   912 PTTGLKGYGGK-LVSRHRLPTS-------CPTSVEELLLRIGLKEYTSVFVLNGYEDLELFKELE 968

  Fly   777 PADLDYLGILNQEHRAKLLTAVQLLHDIE-CSDVDIPGSSSENDEA-RLNNI------------- 826
            |:|||||||.|.|||||:|.|||||||:: .||.|:.||||||||. |||::
Mosquito   969 PSDLDYLGIGNTEHRAKILAAVQLLHDLDSTSDGDVAGSSSENDEGLRLNHVGGLGGSGVGSGNG 1033

  Fly   827 ----NMKHGASPFGRRHFPRDSGCYEGSPLPSSQ-----------------------------TP 858
                ...|..||||||||.||||||||||:||||                             .|
Mosquito  1034 SNGGGGDHQTSPFGRRHFTRDSGCYEGSPVPSSQGSHNSHSYQQQLHHLQQQHQQQLQSHNNGQP 1098

  Fly   859 TQAVN-------------------------STDESNSLDDVVTKCSSEIMKRVESARR------- 891
            .|.:.                         |.:|:|:||.||.:||:||:||||||||
Mosquito  1099 LQPLQQQQQPHGNMATLMGTHHHHLHHHHLSDNETNNLDSVVAQCSNEILKRVESARRYNGTTER 1163

  Fly   892 --CKDNPFKTTLPGGGRLGKKS--------FLGGNGLMADDTLTRGGLSEKSSDSGVSSSSLSSG 946
              .|....:|....||.||...        .:||.|:....  :.|.||||||||||||||||||
Mosquito  1164 GSSKTMNSRTMAKKGGLLGGGGSDGSGGMVMVGGGGVTGGS--SGGALSEKSSDSGVSSSSLSSG 1226

  Fly   947 PLKSS 951
            |.|.|
Mosquito  1227 PAKGS 1231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926	55/60 (92%)
		SH3	657..710	CDD:473055	40/52 (77%)
		SAM_superfamily	742..800	CDD:472832	49/57 (86%)
SKIP	XP_061496559.1	None