DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SKIP and samsn1

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_031752470.1	Gene:	samsn1 / 100497069	XenbaseID:	XB-GENE-993010	Length:	668	Species:	Xenopus tropicalis

Alignment Length:	460	Identity:	131/460 - (28%)
Similarity:	210/460 - (45%)	Gaps:	83/460 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 SHDRESGDYAGSISDLQSVTSRFSTVSIGTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTR 528
            |.||.|.....|..| .::.|..|::|        .::|.:|...:....|..|..::|......
Frog   239 SLDRSSNTKWSSPGD-SALDSDHSSLS--------NWKTFTGNNCDPLVFSIKPIQEWEKCACCN 294

  Fly   529 GHGCLPPSL------------------------------LAAKAKKNGLPHGKANTICQKATVHH 563
            .|..|||||                              |...::...|..|.| |.|.||: |:
Frog   295 HHTQLPPSLTDMDLPYSWRTSSFGAFDRFRKNSVSKPEHLNESSEAESLCEGGA-TECDKAS-HN 357

  Fly   564 SGEMRSSAKEIGAF--NENGRNFVA-----TKDTSRDFSNSQDNTDRGSMSDQAFACSAS-SVES 620
            :|.:....|.|...  .:.|:.::.     |:|.:.::.:.:|:...|.:..:..:..|| ||||
Frog   358 AGSLTKKMKAISLTMRKKMGKKYIQALSEDTQDDTEEYYSHRDSDPEGGIPTEKVSLKASESVES 422

  Fly   621 LPSA-SGSSTQALV---RPGSPHSSISAEDRTSMASCIC-KAKALVDSLPNPYDKEALKFKKGDL 680
            |.|. ||.|:.:.|   ..|:...|:..::..|.....| :||...|..|:|||.::||.||||:
Frog   423 LYSLNSGQSSSSGVTSCSDGTNRDSLRLDEDISYHGPFCGRAKVHTDFTPSPYDMDSLKIKKGDI 487

  Fly   681 IDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGSHNGGPCSV 745
            |:::.....|||.|..|.:||:||||.|:|:.|:.:.          .|...:...|....|.::
Frog   488 IEIICKTPMGIWTGMLHNKVGNFKFIYVDVISEEEIP----------PRRIRARRKSKRPKPKTL 542

  Fly   746 EDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSDVD 810
            ::|:.|:.|::|.|..:|||||.||..|:|:.:.|..|.|.:.|.||:||.|::.|.|.| :|.:
Frog   543 QELMERLNLQDYISSLLLNGYEKLEDLKDLKESHLHELNITSSEERARLLAAIENLQDCE-NDQE 606

  Fly   811 IPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPTQAVNSTDESNSLDDVV 875
            :     ||:...| .::..:.|:.......|||||||  ..|.:|:      ||.||.    :|.
Frog   607 L-----ENESVPL-TLSPGNPANKCELDDCPRDSGCY--ISLETSE------NSKDEV----EVE 653

  Fly   876 TKCSS 880
            |.|.:
Frog   654 TLCEN 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	26/52 (50%)
		SAM	738..801	CDD:197735	24/62 (39%)
		SAM_superfamily	742..800	CDD:301707	24/57 (42%)
samsn1	XP_031752470.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10828
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9435
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910