Protein Alignment SKIP and sash1

DIOPT Version :10

• Sequence 1: NP_001262827.1
• Gene: SKIP / 42601
• FlyBaseID: FBgn0051163
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: XP_002936309.2
• Gene: sash1 / 100379806
• XenbaseID: XB-GENE-1012316
• Length: 1147
• Species: Xenopus tropicalis
• Alignment Length: 1041
• Identity: 233/1041 - (22%)
• Similarity: 369/1041 - (35%)
• Gaps: 330/1041 - (31%)

  Fly   190 QQGPHQHQTLPPNVA------HLNFVQQNCLSPRSAYFYEFPPTAEGRETKKRTTLARLLKGLKT 248
            :|....:.|...||.      |...:.|: |:..|..|....||.|             .:|..:
 Frog    44 EQYADYYNTCTTNVCERMERLHKQHISQD-LNVESLEFSSMLPTLE-------------TEGKLS 94

  Fly   249 VNRRDRNNQQNGAQARAA-NDRLRHF---------QMINGGAGGQQHSFEETIHRLKVQEAMRKK 303
            :::.|..|.::|:..|.. ..:.:||         :::      :|.|..|.:..:..|..|..:
 Frog    95 LHKSDSENSEDGSIGRIYWKKKNKHFWQNFHKSPKEIM------RQTSKGECVDYIASQITMSDE 153

  Fly   304 EKFQ--REHEEILRDIRQGLLQMSRGE--GRMDDT-YMYDEALRTGGGMGIAGLGMPLGVGGNGG 363
            |:.|  ...:|.:..|.:.|.::...|  .||.|| |..|.|
 Frog   154 ERIQLMLMVKEKMITIEEALARLKEYEFQKRMPDTEYSVDWA----------------------- 195

  Fly   364 GGGAAHYAVSALHHQGHWYDEPPYESDPDDFLMAGLNCGPAATIQGGRVR---FSNNRESTGVIS 425
               .|.|  .|.....:.|.....|.:.:|            |::..|::   .|..|....:|.
 Frog   196 ---KALY--PACDKSSNCYSVEQSEDELED------------TVKFKRLQKLVNSTRRVKKKLIR 243

  Fly   426 LRSAGDISLPQRGPPRRGLIVPQQPPNPPTIIP-----LTHARSHDRESGDYAGSISDLQSVTSR 485
            .....|.......|    |:     .|.|.:..     |.:.||.|::..|      .|..|:|.
 Frog   244 TEEGLDDQTIHYSP----LV-----DNTPVLYDVHKKLLCNERSADKKQDD------GLLCVSSS 293

  Fly   486 FS---TVSIGTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTRGHGCLPPSLLAAKAKKN-- 545
            |:   |:::.........::.|||:.::|....:..|..||..|.:    :..|:...:.||:
 Frog   294 FTNKGTINVNRKLVKTLSKSESGGLIKTPKKIGTFFSCPEDEKVQK----VSHSVTEKEMKKSFV 354

  Fly   546 GLPHGKANT--------------------------ICQKATVHHSGEMRSSAKEIGAFNENGRNF 584
            .|.||:.::                          |..:.....|....|.:|::.:..|..:..
 Frog   355 SLNHGRTSSFGGFDLTNRRLHAGNYDEQLEKDVDVIYNEVVKSPSTPRISLSKKVKSVKETMKKK 419

  Fly   585 VATKDTSRDFSNSQDNTDRGSMSDQAFAC-----------------SASSVESLPSA-------S 625
            ::.|.:|  :.:.||     |.:|...|.                 ...|||||.|:       |
 Frog   420 MSKKYSS--YISEQD-----SSTDDILASPEIPQPHISSLEKPQLKEGGSVESLRSSLSGQSSMS 477

  Fly   626 GSSTQALVRPGSPHSSISAE----DRTSMASCIC-KAKALVDSLPNPYDKEALKFKKGDLIDVLS 685
            |.:........|...|:.:|    |..:.....| :|:...|..|:|||.::||.||||:||::|
 Frog   478 GQTVSTTDSSASNRESVKSEDGDDDEPAYRGPFCGRARVHTDFTPSPYDSDSLKLKKGDIIDIIS 542

  Fly   686 MNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLI 750
            ....|.|.|..:.:||.||||.|:||.|...|...|::...|..           .|.||||||.
 Frog   543 KPPMGTWMGLLNNKVGTFKFIYVDVLNEAEKKTKRSRSRGKGLL-----------KPKSVEDLLE 596

  Fly   751 RIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSDVDIPGSS 815
            ||.|||:...|:.||||||:.||.||..|||.|.|.|.||:|.||||::||.:.: |:.|..||
 Frog   597 RINLKEHMPTFLFNGYEDLDAFKLLEEEDLDELNIQNPEHKAVLLTAIELLQEYD-SNSDHSGS- 659

  Fly   816 SENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSP-LPSSQT----PTQAVNSTD--------- 866
               .|.....:....|.|     |  |||||:|.|. |.:.:|    ||.|.:|:.
 Frog   660 ---QEKMHTEVESTSGCS-----H--RDSGCFESSENLKNGKTLRPSPTYAESSSSLDCNRSTKI 714

  Fly   867 ESNSLDDVVTK---------------------------------------CSSEIMKRVESARRC 892
            .|:::::::::                                       |||..:.|.:..:.|
 Frog   715 NSSTVNELLSREAVKLSENRNINKLHSLASCAKSANIIGSKKKGRSLPLLCSSCEIDRAQFVKLC 779

  Fly   893 KDNPFKTTLPGGGR--LGKKSFLGGNGL------------------------------MADDTLT 925
            ..:.....|||..:  ...|.|....|.                              :.|.|.:
 Frog   780 LRSYSLQNLPGATQDATQNKLFSPDKGKEICNFAIDKEGDVHRWISCRVQPVKNFKDELVDATPS 844

  Fly   926 RGGLSEK-----------SSDSGV--------------SSSSLSSGPLK-------SSTXHLPTI 958
            ..|:..:           .|||.|              .||.....|:|       :...|||||
 Frog   845 NSGVKSQEKINLILQHLTKSDSSVRISIPLCSTKVQAKKSSQPPPVPVKKCKGRFVNGLFHLPTI 909

  Fly   959 ----LAHELLLGVGSGMGMGLGLGTMSHGTTGTLTPHGVATATSPTAHSAPLGNICNTLPHAPSS 1019
                ...|..|.       ...:|.:|......|: :.|..:|:||   :|..:....:|..||:
 Frog   910 DSETNTEESFLS-------NTKMGPLSQDDYPKLS-YPVGESTTPT---SPRPSCLPKIPETPSN 963

  Fly  1020 S 1020
            :
 Frog   964 T 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SH3	657..710	CDD:473055	25/52 (48%)
		SAM_superfamily	742..800	CDD:472832	36/57 (63%)
sash1	XP_002936309.2	SLY	357..510	CDD:463602	26/159 (16%)
		SH3_SASH1	512..568	CDD:212900	25/55 (45%)
		SAM_superfamily	587..651	CDD:472832	38/63 (60%)
		SAM_SASH1_repeat2	1066..1132	CDD:188891