DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SKIP and sash1

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	XP_002936309.2	Gene:	sash1 / 100379806	XenbaseID:	XB-GENE-1012316	Length:	1147	Species:	Xenopus tropicalis

Alignment Length:	1041	Identity:	233/1041 - (22%)
Similarity:	369/1041 - (35%)	Gaps:	330/1041 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 QQGPHQHQTLPPNVA------HLNFVQQNCLSPRSAYFYEFPPTAEGRETKKRTTLARLLKGLKT 248
            :|....:.|...||.      |...:.|: |:..|..|....||.|             .:|..:
Frog    44 EQYADYYNTCTTNVCERMERLHKQHISQD-LNVESLEFSSMLPTLE-------------TEGKLS 94

  Fly   249 VNRRDRNNQQNGAQARAA-NDRLRHF---------QMINGGAGGQQHSFEETIHRLKVQEAMRKK 303
            :::.|..|.::|:..|.. ..:.:||         :::      :|.|..|.:..:..|..|..:
Frog    95 LHKSDSENSEDGSIGRIYWKKKNKHFWQNFHKSPKEIM------RQTSKGECVDYIASQITMSDE 153

  Fly   304 EKFQ--REHEEILRDIRQGLLQMSRGE--GRMDDT-YMYDEALRTGGGMGIAGLGMPLGVGGNGG 363
            |:.|  ...:|.:..|.:.|.::...|  .||.|| |..|.|
Frog   154 ERIQLMLMVKEKMITIEEALARLKEYEFQKRMPDTEYSVDWA----------------------- 195

  Fly   364 GGGAAHYAVSALHHQGHWYDEPPYESDPDDFLMAGLNCGPAATIQGGRVR---FSNNRESTGVIS 425
               .|.|  .|.....:.|.....|.:.:|            |::..|::   .|..|....:|.
Frog   196 ---KALY--PACDKSSNCYSVEQSEDELED------------TVKFKRLQKLVNSTRRVKKKLIR 243

  Fly   426 LRSAGDISLPQRGPPRRGLIVPQQPPNPPTIIP-----LTHARSHDRESGDYAGSISDLQSVTSR 485
            .....|.......|    |:     .|.|.:..     |.:.||.|::..|      .|..|:|.
Frog   244 TEEGLDDQTIHYSP----LV-----DNTPVLYDVHKKLLCNERSADKKQDD------GLLCVSSS 293

  Fly   486 FS---TVSIGTNNCTARYRTLSGGIGESPSLSPSPSSDYEDIGVTRGHGCLPPSLLAAKAKKN-- 545
            |:   |:::.........::.|||:.::|....:..|..||..|.:    :..|:...:.||:
Frog   294 FTNKGTINVNRKLVKTLSKSESGGLIKTPKKIGTFFSCPEDEKVQK----VSHSVTEKEMKKSFV 354

  Fly   546 GLPHGKANT--------------------------ICQKATVHHSGEMRSSAKEIGAFNENGRNF 584
            .|.||:.::                          |..:.....|....|.:|::.:..|..:..
Frog   355 SLNHGRTSSFGGFDLTNRRLHAGNYDEQLEKDVDVIYNEVVKSPSTPRISLSKKVKSVKETMKKK 419

  Fly   585 VATKDTSRDFSNSQDNTDRGSMSDQAFAC-----------------SASSVESLPSA-------S 625
            ::.|.:|  :.:.||     |.:|...|.                 ...|||||.|:       |
Frog   420 MSKKYSS--YISEQD-----SSTDDILASPEIPQPHISSLEKPQLKEGGSVESLRSSLSGQSSMS 477

  Fly   626 GSSTQALVRPGSPHSSISAE----DRTSMASCIC-KAKALVDSLPNPYDKEALKFKKGDLIDVLS 685
            |.:........|...|:.:|    |..:.....| :|:...|..|:|||.::||.||||:||::|
Frog   478 GQTVSTTDSSASNRESVKSEDGDDDEPAYRGPFCGRARVHTDFTPSPYDSDSLKLKKGDIIDIIS 542

  Fly   686 MNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGSHNGGPCSVEDLLI 750
            ....|.|.|..:.:||.||||.|:||.|...|...|::...|..           .|.||||||.
Frog   543 KPPMGTWMGLLNNKVGTFKFIYVDVLNEAEKKTKRSRSRGKGLL-----------KPKSVEDLLE 596

  Fly   751 RIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQLLHDIECSDVDIPGSS 815
            ||.|||:...|:.||||||:.||.||..|||.|.|.|.||:|.||||::||.:.: |:.|..||
Frog   597 RINLKEHMPTFLFNGYEDLDAFKLLEEEDLDELNIQNPEHKAVLLTAIELLQEYD-SNSDHSGS- 659

  Fly   816 SENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSP-LPSSQT----PTQAVNSTD--------- 866
               .|.....:....|.|     |  |||||:|.|. |.:.:|    ||.|.:|:.
Frog   660 ---QEKMHTEVESTSGCS-----H--RDSGCFESSENLKNGKTLRPSPTYAESSSSLDCNRSTKI 714

  Fly   867 ESNSLDDVVTK---------------------------------------CSSEIMKRVESARRC 892
            .|:::::::::                                       |||..:.|.:..:.|
Frog   715 NSSTVNELLSREAVKLSENRNINKLHSLASCAKSANIIGSKKKGRSLPLLCSSCEIDRAQFVKLC 779

  Fly   893 KDNPFKTTLPGGGR--LGKKSFLGGNGL------------------------------MADDTLT 925
            ..:.....|||..:  ...|.|....|.                              :.|.|.:
Frog   780 LRSYSLQNLPGATQDATQNKLFSPDKGKEICNFAIDKEGDVHRWISCRVQPVKNFKDELVDATPS 844

  Fly   926 RGGLSEK-----------SSDSGV--------------SSSSLSSGPLK-------SSTXHLPTI 958
            ..|:..:           .|||.|              .||.....|:|       :...|||||
Frog   845 NSGVKSQEKINLILQHLTKSDSSVRISIPLCSTKVQAKKSSQPPPVPVKKCKGRFVNGLFHLPTI 909

  Fly   959 ----LAHELLLGVGSGMGMGLGLGTMSHGTTGTLTPHGVATATSPTAHSAPLGNICNTLPHAPSS 1019
                ...|..|.       ...:|.:|......|: :.|..:|:||   :|..:....:|..||:
Frog   910 DSETNTEESFLS-------NTKMGPLSQDDYPKLS-YPVGESTTPT---SPRPSCLPKIPETPSN 963

  Fly  1020 S 1020
            :
Frog   964 T 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	25/52 (48%)
		SAM	738..801	CDD:197735	36/62 (58%)
		SAM_superfamily	742..800	CDD:301707	36/57 (63%)
sash1	XP_002936309.2	SLY	357..510	CDD:372142	26/159 (16%)
		SH3_SASH1	512..568	CDD:212900	25/55 (45%)
		SAM_superfamily	587..651	CDD:387673	38/63 (60%)
		SAM_SASH1_repeat2	1066..1132	CDD:188891
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8992
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9435
Panther	1	1.100	-	-	O	PTHR12301
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.100