Protein Alignment how and khdrbs2

DIOPT Version :10

• Sequence 1: NP_001262822.1
• Gene: how / 42596
• FlyBaseID: FBgn0264491
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_001072215.1
• Gene: khdrbs2 / 779662
• XenbaseID: XB-GENE-490722
• Length: 345
• Species: Xenopus tropicalis
• Alignment Length: 378
• Identity: 114/378 - (30%)
• Similarity: 177/378 - (46%)
• Gaps: 92/378 - (24%)

  Fly    78 YLAQLLKDRKQLAAFPNVFTHVERLLDEEIARVRASLFQINGVKKEPLTLPEPEGSVVTMNEKVY 142
            ||.:|:.::..|.  |: |.|..|||||||.:.:.|.......:|:.|.:...:.  :.::|:|.
 Frog     6 YLPELMAEKDSLD--PS-FVHAMRLLDEEIVKFQDSEGNKEDGEKKYLDIISNKN--IKLSERVL 65

  Fly   143 VPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANR--GKPNWEHLSDD 205
            :||:::|.|||||::|||||.:.|:|::|||.|:.:.||||||||.||:..|  .:....||||:
 Frog    66 IPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKIKEEELRKSDEAKHAHLSDE 130

  Fly   206 LHVLITVEDTENRATVKLAQAVAEVQKLLVPQAEGEDELKKRQLMELAIINGT-----YRDTTAK 265
            ||||:.|......|..:::.|:.|::|.|||  :..||:::.||.||:.:||:     .:.|..:
 Frog   131 LHVLLEVFAPPGEAYSRMSHALEEIKKFLVP--DYNDEIRQEQLRELSYLNGSDDSERGKGTRGR 193

  Fly   266 SVAAFSCVGSASYLYPAVCDEEWRRLVAASDSRL---LTSTGLPGLAAQIRAPAAAPLGAPLILN 327
            .:.                       |.::.||.   :.|...||..      |:|..|||:
 Frog   194 GIR-----------------------VPSTPSRNRGGVISPAFPGRG------ASATRGAPI--- 226

  Fly   328 PRMTVPTTAASILS--AQAAPTA------------AFDQTGHGMIFA-PYDYANYAALAGN---- 373
            .|.|:.|.|..|.:  |:||||.            .:|..|:...|. .||..:|.....|
 Frog   227 TRGTISTVARGIPTPRAKAAPTTPGYRLPPPLTIETYDDYGYDDGFGEDYDEQSYDIYENNYNSQ 291

  Fly   374 -PLLTEYADHS--------------------GAIK---QQRRLATNREHPYQR 402
             ..::||.|:.                    ..:|   |:...|..|||||.|
 Frog   292 TQSVSEYYDYEHGTNEESYNHYEQEEWSKSRSTLKAPLQRPARAGYREHPYGR 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..122	CDD:435414	15/43 (35%)
		KH-I_HOW	132..236	CDD:411894	46/105 (44%)
khdrbs2	NP_001072215.1	Qua1	5..57	CDD:465079	17/53 (32%)
		KH-I_KHDRBS2	54..171	CDD:411897	50/120 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	178..224		11/74 (15%)
		Sam68-YY	263..317	CDD:465182	10/53 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	321..345		9/24 (38%)