Protein Alignment how and SF1

DIOPT Version :10

• Sequence 1: NP_001262822.1
• Gene: how / 42596
• FlyBaseID: FBgn0264491
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_001365886.1
• Gene: SF1 / 7536
• HGNCID: 12950
• Length: 764
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 104/457 - (22%)
• Similarity: 176/457 - (38%)
• Gaps: 134/457 - (29%)

  Fly    37 AQAQAQAQAQQQQQAPQVVVPMTPQHLTP---QQQQQSTQSIADYLAQL-LKD--RK----QLAA 91
            ::.:.:::..|.....:.|:|..|..:.|   ::|:::      |:.|| ::|  ||    .|..
Human   139 SKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERA------YIVQLQIEDLTRKLRTGDLGI 197

  Fly    92 FPN----------VFT-----------HVERLLDEEIARVRASLFQINGVKKEPLTLPEPEGSVV 135
            .||          ::.           ...:.|:||...:...:..:|...|.|.....|   ..
Human   198 PPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPP---AT 259

  Fly   136 TMNEKVYVPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANRGKPNWE 200
            .:::||.:|..|:|:.||||.::||||.|.|.:|:|...|||:|||||:::.|.     |:.:.:
Human   260 RVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKV-----GRKDGQ 319

  Fly   201 HL---SDDLHVLITVEDTENRATVKLAQAVAEVQKLL---VPQAEGEDELKKRQLMELAIINGTY 259
            .|   .:.||.|:|....||     :.:||.:::.:|   :...|.:::|:|.||.|||.:|||.
Human   320 MLPGEDEPLHALVTANTMEN-----VKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTL 379

  Fly   260 RDTTAKSVAAFSCVGSASYLYPAVC------------------------------DEEWRRLVAA 294
            |:...:.:..:....:.|.....||                              |:|:..|:|.
Human   380 REDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAE 444

  Fly   295 SDSRLLTSTGLPGLAAQIRAPAAAPLGAPLILNPRMTVPTT---AASILS-AQAAPTAAFDQTGH 355
                 |....:|........||..||.:.    ||...|..   ..|::| .|:.|.
Human   445 -----LGEAPVPASVGSTSGPATTPLASA----PRPAAPANNPPPPSLMSTTQSRPP-------- 492

  Fly   356 GMIFAPYDYANYAALAG--------------NPLLTEYADHSGAIKQQRRLATNREHPYQRATVG 406
            .|...|.:...|..:.|              :||.:....|.|             ||.|....|
Human   493 WMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGG-------------HPMQHNPNG 544

  Fly   407 VP 408
            .|
Human   545 PP 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..122	CDD:435414	13/74 (18%)
		KH-I_HOW	132..236	CDD:411894	37/109 (34%)
SF1	NP_001365886.1	MSL5	142..382	CDD:227503	71/258 (28%)
		ZnF_C2HC	403..418	CDD:197667	2/14 (14%)