Protein Alignment how and Khdrbs3

DIOPT Version :10

• Sequence 1: NP_001262822.1
• Gene: how / 42596
• FlyBaseID: FBgn0264491
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_071585.2
• Gene: Khdrbs3 / 64015
• RGDID: 620921
• Length: 346
• Species: Rattus norvegicus
• Alignment Length: 354
• Identity: 106/354 - (29%)
• Similarity: 162/354 - (45%)
• Gaps: 45/354 - (12%)

  Fly    78 YLAQLLKDRKQLAAFPNVFTHVERLLDEEIARVRASLFQINGVKKEPLTLPEPEGSVVTMNEKVY 142
            ||.:|:.::..|.  |: |||..||::.||.:     ||....|.|...:.......:.:.:||.
  Rat     5 YLPELMAEKDSLD--PS-FTHALRLVNREIEK-----FQKGEAKDEEKYIDVVINKNMKLGQKVL 61

  Fly   143 VPVREHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKEDANR--GKPNWEHLSDD 205
            :||::.|.|||||::|||||.:.|:|::||..|:.:.||||||||.||:..|  |:..:.||:||
  Rat    62 IPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDD 126

  Fly   206 LHVLITVEDTENRATVKLAQAVAEVQKLLVPQAEGEDELKKRQLMELAIINGTYRDTTAKSVAAF 270
            |||||.|......|..::..|:.|::|.|:|  :..||:::.||.||..:||...:.....|...
  Rat   127 LHVLIEVFAPPAEAYARMGHALEEIKKFLIP--DYNDEIRQAQLQELTYLNGGSENADVPVVRGK 189

  Fly   271 SCVGSASYLYPAVCDEE---WRRLVAASDSRLLTSTGLPGLAAQIRAPAAAPLGAPLILNPRMT- 331
            |.:.:.....||:....   ..|.||....|   .|..|......|.|.:...|   :|.||..
  Rat   190 STLRTRGVTTPAITRGRGGVTARPVAVGVPR---GTPTPRGVLSTRGPVSRGRG---LLTPRARG 248

  Fly   332 VPTTAASILSAQAAPTAAFDQT--------GHGMIFAPYDYANYAALAGNPLLT--EYADHSGAI 386
            ||.|     ..:..|.....:|        |:...:....|.:|......|..:  :|.|:...:
  Rat   249 VPPT-----GYRPPPPPPTQETYGEYDYDDGYSTAYDDQSYDSYDNSYSTPAQSGADYYDYGHGL 308

  Fly   387 KQQ------RRLATNREH--PYQRATVGV 407
            .::      :...||..|  |..|...||
  Rat   309 GEEAYDSYGQEDWTNSRHKAPSARTAKGV 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..122	CDD:435414	14/43 (33%)
		KH-I_HOW	132..236	CDD:411894	47/105 (45%)
Khdrbs3	NP_071585.2	Involved in homodimerization. /evidence=ECO:0000250|UniProtKB:O75525	1..160		64/164 (39%)
		Qua1	4..53	CDD:465079	16/55 (29%)
		KH-I_KHDRBS3	48..160	CDD:411898	48/113 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..268		17/66 (26%)
		Sam68-YY	266..320	CDD:465182	6/53 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..346		7/18 (39%)