Protein Alignment how and how

DIOPT Version :10

• Sequence 1: NP_001262822.1
• Gene: how / 42596
• FlyBaseID: FBgn0264491
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: XP_001238186.2
• Gene: how / 4577936
• VectorBaseID: AGAMI1_006092
• Length: 378
• Species: Anopheles gambiae
• Alignment Length: 373
• Identity: 251/373 - (67%)
• Similarity: 280/373 - (75%)
• Gaps: 32/373 - (8%)

  Fly    40 QAQAQAQQQQQAPQVVVPMTPQHLTPQQQQQSTQSIADYLAQLLKDRKQLAAFPNVFTHVERLLD 104
            |.|.|.|||||.|              .|||||||||||||||||||||||||||||.|:|||||
Mosquito    26 QQQQQQQQQQQQP--------------NQQQSTQSIADYLAQLLKDRKQLAAFPNVFLHIERLLD 76

  Fly   105 EEIARVRASLFQINGVKKEPLTLPEPEGSVVTMNEKVYVPVREHPDFNFVGRILGPRGMTAKQLE 169
            |||::||||||.||||.||||.||:|||..||:||||||||:|:|||||||||||||||||||||
Mosquito    77 EEISKVRASLFHINGVTKEPLQLPDPEGESVTLNEKVYVPVKEYPDFNFVGRILGPRGMTAKQLE 141

  Fly   170 QETGCKIMVRGKGSMRDKKKEDANRGKPNWEHLSDDLHVLITVEDTENRATVKLAQAVAEVQKLL 234
            |||||||||||||||||||||||||||||||||||||||||||||||||||:||.:|:.||:|||
Mosquito   142 QETGCKIMVRGKGSMRDKKKEDANRGKPNWEHLSDDLHVLITVEDTENRATIKLKRALDEVKKLL 206

  Fly   235 VPQAEGEDELKKRQLMELAIINGTYRDTTAKSVAAFSCVGSASYLYPAVCDEEWRRLVAAS--DS 297
            ||.||||||||||||||||||||||||:|.|...|.:........|   .|:.|:...|||  |.
Mosquito   207 VPHAEGEDELKKRQLMELAIINGTYRDSTTKVAPADNTFSFDPQQY---TDDRWKMAAAASAADQ 268

  Fly   298 RLLTSTGLPGLAAQIRA-------PAAAPLGAPLILNPRMTVPTTAASILSAQAAPTAAFDQTGH 355
            |:||...| ..||.:.|       .|..|||||:||:||::|||||||::.. :.|....|.| .
Mosquito   269 RMLTQASL-AAAANLAAANQMAGRTAPNPLGAPIILSPRISVPTTAASLIPG-SGPPPTIDHT-T 330

  Fly   356 GMIFA-PY-DYANYAALAGNPLLTEYADHS-GAIKQQRRLATNREHPY 400
            |:|:| || ||:...|.||||||||||||| ||||..||...:|:|||
Mosquito   331 GLIYASPYTDYSYALAAAGNPLLTEYADHSVGAIKNPRRQYASRDHPY 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
how	NP_001262822.1	STAR_dimer	75..122	CDD:435414	41/46 (89%)
		KH-I_HOW	132..236	CDD:411894	92/103 (89%)
how	XP_001238186.2	None